维生素D在克罗恩病发病机制中的作用及应用前景

Q3 Medicine
K. Ivashkin, V. R. Grechishnikova, M. Reshetova, O. Zol’nikova, V. Leschenko, A. Sedova, E. Bueverova, V. Ivashkin
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引用次数: 0

摘要

许多研究表明,维生素D具有多种作用,包括免疫调节和克罗恩病的发病机制。因此,活性维生素D代谢物的浓度可能与疾病的发生、进展和严重程度有关。维生素D的骨骼和骨骼外作用是通过其活性代谢物- 1.25(OH)2D实现的,这是一种类固醇激素。这项工作的目的是:分析积累的证据,证明维生素D在克罗恩病的发病机制中有多种作用,并确定使用维生素作为该疾病综合治疗的一部分的可能前景。尽管体外和动物研究的数据表明维生素D在克罗恩病发病机制中的多重作用,但目前基于基础临床试验的现有证据尚不足以将维生素D纳入克罗恩病治疗的临床指南。进一步的研究工作是必要的。关键词:克罗恩病,维生素D,钙化醇,维生素D轴,骨骼外作用
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Vitamin D in Crohn’s disease: involvement in pathogenesis and application prospects
As many research works show, vitamin D has pleiotropic effects, including the immune regulation and pathogenesis of Crohn’s disease. Therefore, concentrations of the active vitamin D metabolite might be associated with the development, progression and severity of the disease. The skeletal and extraskeletal effects of vitamin D are realised through its active metabolite – 1.25(OH)2D, which is a steroid hormone. The objective of the work: to analyse the accumulated evidence demonstrative of a multiple contribution of vitamin D in the pathogenesis of Crohn’s disease, and to determine the possible perspectives of using the vitamin as part of comprehensive therapy of this disease. Despite the fact, that data of in vitro and animal studies are demonstrative of multiple effects of vitamin D in the pathogenesis of Crohn’s disease, the currently available evidence based on the underlying clinical trials are insufficient yet for including vitamin D in clinical guidelines on management of Crohn’s disease. Further research work is necessary. Key words: Crohn’s disease, vitamin D, calciferol, vitamin D axis, extraskeletal effects
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来源期刊
Voprosy Detskoi Dietologii
Voprosy Detskoi Dietologii Medicine-Pediatrics, Perinatology and Child Health
CiteScore
1.20
自引率
0.00%
发文量
17
期刊介绍: The scientific journal Voprosy Detskoi Dietologii is included in the Scopus database. Publisher country is RU. The main subject areas of published articles are Food Science, Pediatrics, Perinatology, and Child Health, Nutrition and Dietetics, Клиническая медицина.
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