氧化应激:胰岛素分泌、激素摄入、脂肪组织脂肪酶的影响

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL
Виктор Владимирович Иванов, Е. В. Шахристова, Е. А. Степовая, О. Л. Носарева, Т. С. Фёдорова, Наталья Владимировна Рязанцева, Вячеслав Викторович Новицкий
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引用次数: 1

摘要

氧化应激是许多疾病的致病因素之一,在此过程中,活性氧的产生增加,抗氧化保护系统的能力下降。在过去几十年的研究中,人们特别关注脂肪组织、脂肪因子的产生及其在与代谢综合征和糖尿病形成相关的免疫抵抗发展中的作用。寻找治疗性纠正脂肪因子分泌紊乱的方法,它们对分离细胞和整个生物体代谢的影响,以及开发新的方法来纠正细胞对胰岛素敏感性紊乱,是当今非常热门的话题。对积累的数据进行系统化和整合,可以更准确地确定进一步研究的策略;因此,我们试图总结和分析脂肪组织在氧化应激发展中的作用的累积数据。本文在文献资料和个人调查的基础上,分析了脂肪组织在糖尿病氧化应激形成中的作用。简要介绍了脂肪组织作为调节脂肪细胞代谢过程和影响身体各器官和系统功能的分泌器官。胰岛素分泌紊乱的机制以及I型糖尿病胰岛素抵抗的发展,以及脂肪组织中脂肪分解对这些过程的贡献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Окислительный стресс: влияние на секрецию инсулина, рецепцию гормона адипоцитами и липолиз в жировой ткани
Oxidative stress is one of the pathogenetic components of many diseases during which generation of reactive oxigen species increases and the capacity of the antioxidant protection system diminishes. In the research of the last decades special attention has been given to adipose tissue, production of adipokines by it and their role in development of immunoresistance associated with formation of the metabolic syndrome and diabetes. Search for methods of therapeutic correction of adipokine secretion disorders, their influence on metabolism of separate cells and the organism on the whole as well as development of new approaches to correction of disorders in cell sensitivity to insulin are extremely topical nowadays. Systematization and consolidation of accumulated data allow to determine the strategies of further research more accurately; as a result, we have attempted to summarize and analyze the accumulated data on the role of adipose tissue in oxidative stress development. On the basis of literature data and the results of the personal investigations, the role of adipose tissue in forming oxidative stress in diabetes has been analyzed in the article. Brief description of adipose tissue was given as a secretory organ regulating metabolic processes in adipocytes and influencing functions of various organs and systems of the body. Mechanisms of disorder in insulin secretion as well as development of insulin sesistance in type I diabetes were described along with the contribution of lipolysis in adipose tissue to these processes.
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来源期刊
Byulleten Sibirskoy Meditsiny
Byulleten Sibirskoy Meditsiny MEDICINE, GENERAL & INTERNAL-
CiteScore
0.70
自引率
50.00%
发文量
102
审稿时长
8 weeks
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