水杨酸基质子离子液体作为潜在的抗氧化剂

Q4 Chemistry

Malaysian Journal of Analytical Sciences Pub Date : 2019-01-01 DOI:10.17576/mjas-2019-2303-02

N. Ahmad, K. Jumbri, A. Ramli, N. Ghani, H. Ahmad

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引用次数: 1

摘要

本文对水杨酸基质子离子液体进行了合成、表征和评价，并对其在药物设计中的潜在抗氧化作用进行了评价。合成的pil分别被称为3-二甲氨基-1-丙醇水杨酸酯(3DMAPS)和3-二乙基氨基-1丙醇水杨酸酯(3DEAPS)。利用质子核磁共振(HNMR)、傅里叶变换红外光谱(FTIR)和热重分析(TGA)对合成的PILs进行了表征。此外，用2,2-二苯基-1-苦味酰肼(DPPH)自由基法测定了合成的白蛋白的抗氧化活性。3DMAPS和3DEAPS在浓度分别为66.76±0.09 μM和27.27±0.10 μM时，对DPPH自由基的清除能力均优于母体酸(水杨酸)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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SALICYLATE-BASED PROTIC IONIC LIQUIDS AS A POTENTIAL ANTIOXIDANT

Salicylate-based protic ionic liquids (PILs) were synthesised, characterised and assessed in this study for potential antioxidant in drug design. The synthesised PILs were known as 3-dimethylamino-1-propanol salicylate (3DMAPS) and 3-diethylamino-1propanol salicylate (3DEAPS). Proton nuclear magnetic resonance (HNMR), Fourier transformation infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA) were used to characterise the synthesised PILs. Furthermore, the antioxidant activity of the synthesised PILs was determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical assay. Both 3DMAPS and 3DEAPS showed a good antioxidant activity compared to parent acid (salicylic acid) as these two compounds could scavenge 20% of DPPH free radical at a concentration of 66.76 ± 0.09 μM and 27.27 ± 0.10 μM, respectively.

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来源期刊

Malaysian Journal of Analytical Sciences Chemistry-Analytical Chemistry

CiteScore

1.10

自引率

0.00%

发文量