抗抑郁药物(丙咪嗪和氟西汀)对雌性Wistar大鼠卵巢基因转录的影响

Q4 Veterinary

Journal of Experimental Biology and Agricultural Sciences Pub Date : 2023-06-30 DOI:10.18006/2023.11(3).593.597

Oyedeji K.O, Uwadiale D.

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引用次数: 0

摘要

本研究旨在研究雌性大鼠对抗抑郁药物(丙咪嗪和氟西汀)的卵巢基因转录反应。雌性大鼠15只，体重120 ~ 140 g。丙咪嗪(0.71 mg/kg)和氟西汀(0.57 mg/kg)口服50 d。采用RT-PCR方法检测FSH-R、p53和Bcl-2基因的表达。使用GraphPad Prism 8.0版本生成图像为平均+/- SEM。研究结果显示，与对照组相比，丙咪嗪组大鼠FSH-R、p53和Bcl-2的表达明显上调(p<0.05)。综上所述，丙咪嗪可诱导雌性Wistar大鼠卵泡生长和凋亡。

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Ovarian Gene Transcriptional Responses To Antidepressant Drugs (Imipramine And Fluoxetine) In Female Wistar Rats

This study was designed to investigate ovarian gene transcriptional responses to selected antidepressant drugs (imipramine and fluoxetine) in female rats. Fifteen female rats (120 – 140 g) were used for this study. Imipramine (0.71 mg/kg) and fluoxetine (0.57 mg/kg) were given orally for 50 days. The method of RT-PCR was employed to investigate the expressions of FSH-R, p53 and Bcl-2 genes. Graphics were generated as mean +/- SEM using GraphPad Prism version 8.0. Results of the study revealed that the FSH-R, p53 and Bcl-2 expressions were significantly (p<0.05) up-regulated in the imipramine-treated rats relative to their controls. Conclusively, it can be suggested that imipramine induced follicular growth and apoptosis in female Wistar rats.

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来源期刊

Journal of Experimental Biology and Agricultural Sciences Agricultural and Biological Sciences-Agricultural and Biological Sciences (all)

CiteScore

1.00

自引率

0.00%

发文量

127