Δ9-tetrahydrocannabinol(大麻,大麻)和大麻素呕吐综合征之间的关系

S. Lipson
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引用次数: 0

摘要

医用(和娱乐)大麻的适度使用据称可以减轻肿瘤疾病、化疗、神经病变、炎症、肌肉痉挛等患者的疼痛和不适[1,2]。从病因学上讲,大麻的过度使用与出现严重胃肠道痉挛、周期性腹泻、恶心和呕吐的患者有关,临床称为大麻素充血综合征或CHS[3]。虽然一度被认为是罕见的,但在过去几年里,CHS显著增加。例如,从两家城市医院急诊科获得的数据显示,1 / 3的大麻使用者被诊断患有CHS[4,5]。滥用大麻不被认为是危及生命的,尽管有两例由于非特异性电解质失衡导致的与chs相关的死亡报告[10]。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between Δ9-tetrahydrocannabinol (cannabis, marijuana) and the cannabinoid hyperemesis syndrome
The use of medical (and recreational) cannabis in moderation, has been purported to ameliorate pain and discomfort from patients suffering from the effects of neoplastic diseases, administration of chemotherapy, neuropathy, inflammation, muscle spasticity and more [1,2]. The inordinate use of cannabis paradoxically, has been etiologically linked to patients presenting with intense gastrointestinal cramps, cyclical diarrhea, nausea, and vomiting clinically referred to as cannabinoid hyperemesis syndrome or CHS [3]. Although once considered rare, CHS has markedly increased over the last number of years. Data obtained from two urban hospital Emergency Departments for example, showed > one third of cannabis users being diagnosed with CHS [4,5]. The abuse of cannabis is not considered life threatening, although two CHS-associated mortalities due to nonspecific electrolyte imbalances have been reported [6].
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