Novel coronavirus infection and pregnancy: features of the course of gestation and the possibility of predicting the progression of COVID-19 severity in pregnant women

The authors analyzed the literature data on the possibility of timely diagnosis and prognosis of COVID-19 progression and development of life-threatening complications during gestation. Pregnant women are at high risk for a severe course of the disease, which is inherent in the prerequisites of gestational adaptation mechanisms. This review presents various aspects of COVID-19 and pregnancy, ranging from the etiopathogenesis and clinical features of the course of the disease in pregnant women to highly informative laboratory methods for predicting the severity of COVID-19. The studies presented demonstrate the scientific and practical interest in developing and implementing pathogenetically valid markers to stratify pregnant women at risk for COVID-19 progression and adverse gestational, perinatal, and somatic outcomes. The current knowledge and practice are insufficient for their large-scale application to effectively address the challenges of timely diagnosis of COVID-19 severity and the prognosis of life-threatening complications, prolonged course of disease, or postconceptional syndrome, which is essential to maintain quality of life, fully develop the biological system of mother and newborn, and preserve reproductive potential. © 2023, Media Sphera Publishing Group. All rights reserved.