预测COVID-19幸存者慢性心力衰竭风险的临床和实验室指标

Profilakticheskaya Meditsina Pub Date : 2023-01-01 DOI:10.17116/profmed20232604177

A. O. Shabelsky, A. V. Levshin, P. Astanin, A.E. Kolesova, Ya.E. Nureeva, A. Svarovskaya

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引用次数: 0

摘要

冠状病毒病具有许多全身性疾病症状，并对心血管系统造成严重后果。目标。评估临床和实验室指标在确定covid -19幸存者慢性心力衰竭(CHF)风险中的作用。材料和方法。回顾性选择2015年11月3日至21年10月10日在某单一感染医院就诊的确诊COVID-19患者151例。通过查阅电子病历收集病史和实验室数据。数据包括年龄、性别、体重指数、吸烟状况和合并症。实验室数据包括血液学和血液化学、凝血和急性期蛋白水平的结果。CHF的发生作为研究终点。结果和讨论。根据是否存在CHF将研究患者分为两组:1组包括46例CHF患者，2组包括105例无CHF患者。中位年龄为66.2岁(50-92岁)，女性91例(60.3%)。实验室测试，如hs- c反应蛋白、乳酸脱氢酶、降钙素原、肌酐和胆红素水平，在研究组患者中有统计学显著差异，并且中位值在CHF患者中更高。中性粒细胞-淋巴细胞比率(NLR)组间差异有统计学意义:CHF患者中位值为4.97%，非CHF患者中位值为3.62% (p=0.011)。CHF风险增加的最显著预测因子是年龄>=66岁(OR=8.038, p=0.09 ng/mL) (CHF风险增加3.8倍，p=4.11% (p=0.010)和慢性肾脏疾病史(p=0.018)。结论。已经开发了一个模型来确定与covid -19幸存者慢性心力衰竭风险密切相关的因素。版权所有©Media Sphera出版集团2023版权所有。

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Clinical and laboratory indicators in predicting the risk of chronic heart failure in COVID-19 survivors

Coronavirus disease has many systemic disease symptoms and has severe consequences for the cardiovascular system. Objective. To assess the role of clinical and laboratory indicators in determining the risk of chronic heart failure (CHF) in COV-ID-19 survivors. Material and methods. In total, 151 patients treated in a monoinfectious hospital from 03.11.20 to 10.02.21 with a confirmed diagnosis of COVID-19 were retrospectively selected. Medical history and laboratory data were collected by reviewing electronic medical records. The data included age, gender, body mass index, smoking status, and comorbidities. The laboratory data included the results of hematology and blood chemistry, coagulation, and the levels of acute-phase proteins. The CHF occurrence was used as the study endpoint. Results and discussion. The study patients were divided into two groups depending on the presence of CHF: group 1 included 46 patients with CHF, and group 2 included 105 patients without CHF. The median age was 66.2 (50-92) years;91 (60.3%) were females. Laboratory tests, such as levels of the hs-C-reactive protein, lactate dehydrogenase, procalcitonin, creatinine, and bilirubin, were statistically significantly different in patients of the study groups, and the median values were higher in patients with CHF. Neutrophil-lymphocyte ratio (NLR) showed statistically significant differences between groups: in patients with CHF, the median was 4.97% compared to 3.62% (p=0.011) in those without CHF. The most significant predictors of an increased risk of CHF were age >=66 years (OR=8.038, p<0.001), procalcitonin level >=0.09 ng/mL (increased the CHF risk by 3.8 times, p<0.001), thrombocy-topenia <=220x109/L (p=0.010), an NLR ratio >=4.11% (p=0.010), and a history of chronic kidney disease (p=0.018). Conclusion. A model has been developed to determine the factors closely associated with the risk of chronic heart failure in CO-VID-19 survivors.Copyright © 2023, Media Sphera Publishing Group. All rights reserved.

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来源期刊

Profilakticheskaya Meditsina Medicine-Health Policy

CiteScore

0.90

自引率

0.00%

发文量

108

期刊介绍： The journal "Profilakticheskaya meditsina" (The Russian Journal of Preventive Medicine and Public Health) has been published since 1997 and is intended for healthcare professionals and administrators, politicians, and scientists. A wide range of problems appearing on the pages of the journal is determined by its sociopolitical and scientific-and-practical orientations. The journal covers the problems of health promotion, the prevention and treatment of communicable and non-communicable diseases, such as cardiovascular and respiratory diseases, cancers, diabetes, injuries, and violent death. The main sections of the journal: Organization of Public Health Prevention of Communicable and Non-Communicable Diseases, Health Promotion: Policy and Strategy Sociomedical Aspects of Health Formation Medico-Demographic Aspects of Health Formation Prevention of Communicable and Non-Communicable Diseases Risk Factors for Communicable and Non-Communicable Diseases The Health of Children, Adolescents, and Young People Female Health Male Health Nutrition and Health Smoking and Health Alcohol and Health Guidelines for the Specialist Education Programs for Healthcare Specialists and Patients Experience of Regions A Specialist’s Opinion Reviews.