空气阻抗静电纺聚二氧环酮模板的制备与表征

Gretchen S. Selders, A. Fetz, Shannon L. Speer, G. Bowlin
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引用次数: 6

摘要

静电纺丝是一种利用天然和合成聚合物制造无纺布多孔模板的制造技术,由于其高度可定制性,在组织工程中被广泛使用。然而,传统的静电纺丝产生了限制性的孔大小,限制了所需的细胞迁移。因此,组织工程小组一直在寻求提高和调节组织工程模板的孔隙率。空气阻抗静电纺丝产生具有可定制的、有图案的低密度和高密度纤维沉积区域的模板。在这里,我们展示了一种改进的空气阻抗静电纺丝系统,由一个新设计的漏斗组成,该漏斗用于容纳可变多孔沉积板,并以受限和集中的方式管理空气流动,其参数保持模板的完整性。在这项初步研究中,我们使用传统的纤维和孔隙分析以及汞孔隙度法量化了聚二氧环酮模板孔隙度的增加。此外,我们验证了系统在制造增强孔隙度模板方面的重要性,尽管孔隙度故意增加,但仍能保持其机械性能(即弹性模量、抗拉强度和缝合保持强度)。这对模板的完整性和有效性具有特殊的价值,因为这些参数可以进一步优化,以获得给定应用所需的模板孔隙率、强度和纹理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fabrication and characterization of air-impedance electrospun polydioxanone templates
Abstract Electrospinning, a fabrication technique used to create non-woven, porous templates from natural and synthetic polymers, is commonly used in tissue engineering because it is highly tailorable. However, traditional electrospinning creates restrictive pore sizes that limit the required cell migration. Therefore, tissue engineering groups have sought to enhance and regulate porosity of tissue engineering templates. Air-impedance electrospinning generates templates with tailorable, patterned areas of low and high density fiber deposition. Here we demonstrate an improved air-impedance electrospinning system, consisting of a newly designed funnel equipped to hold changeable porous deposition plates and administer air flow in a confined and focused manner, with parameters that maintain template integrity. In this preliminary study, we quantify the increase in porosity of polydioxanone templates with use of traditional fiber and pore analysis as well as with mercury porosimetry. Additionally, we validate the system’s significance in fabricating enhanced porosity templates that maintain their mechanical properties (i.e. elastic modulus, tensile strength, and suture retention strength) despite the deliberate increase in porosity. This is of exceptional value to the template’s integrity and efficacy as these parameters can be further optimized to induce the desired template porosity, strength, and texture for a given application.
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