I. Davidson, N. Osidze, A. Altory, I. Raibshtein, Ezra Rozenbluth, Yigal Parnoushi, E. Spackman
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引用次数: 4
摘要
H9N2亚型禽流感病毒在亚洲和中东流行。以色列H9N2 (G1谱系)由自2000年以来在该国检测到的五个系统发育分支组成。通过对SPF鸡的免疫攻毒试验，评价了种属间遗传差异对疫苗效力的影响。利用以色列H9亚型IV和V分离株，用Montanide ISA 70VG佐剂制备实验疫苗。不同遗传支系和抗原组的H9 AIV毒株攻毒时提供了相似的保护，表明存在交叉遗传支系保护(即病毒脱落量和脱落病毒的鸡数量减少)。值得注意的是，两种实验性疫苗的保护作用高度依赖于攻毒病毒的感染剂量。
Antigenically and Genetically Diverse Isolates of Low Pathogenicity H9N2 Avian Influenza Virus Provide Cross-Clade Vaccinal Protection
Avian influenza viruses, H9N2 subtype, are endemic in Asia and the Middle East. The Israeli H9N2 (G1 lineage) consists of five phylogenetic clades that were detected in the country since the year 2000. The influence of the inter-clade genetic differences on vaccine efficacy was evaluated by vaccination-challenge trials in specific pathogen free (SPF) chickens. Experimental vaccines utilizing isolates belonging to Israeli H9 clades IV and V were prepared with Montanide ISA 70VG adjuvant. When challenged with H9 AIV strains from different genetic clades and antigenic groups provided similar protection, indicating the existence of cross-genetic clade protection (i.e. reduction in amount of virus shed and number of chickens shedding virus). Notably, the protection conferred by both experimental vaccines was highly dependent on the infection dose of the challenge virus.
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