疫苗接种和自闭症:证据和疫苗依从性在澳大利亚

Isaac Golden
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引用次数: 1

摘要

导言:澳大利亚政府卫生网站称,疫苗接种和自闭症之间没有联系。这些说法影响了澳大利亚围绕疫苗接种的公共卫生政策。方法:对四个澳大利亚和一个美国政府网站进行了检查,以确定审查疫苗接种与自闭症之间联系的原始研究文章。有关疫苗接种和自闭症的说法主要基于23篇原创研究文章。对相关文章进行了分析,以确定是否对完全接种疫苗(V)和完全未接种疫苗(CUV)的儿童进行了比较。结果:没有一篇文章对V型和CUV型儿童进行了实质性的比较。他们确实表明,在不同接种疫苗的儿童群体中,自闭症发病率没有显著差异,但如果没有V型和CUV型儿童的比较,他们无法就自闭症和疫苗之间的联系得出任何最终结论。讨论:为了评估是否可以进行适当的研究以进一步检查疫苗接种与自闭症之间的任何可能的联系,估计了澳大利亚适龄队列中未接种疫苗的儿童数量。发现了足够的数字,可以作出具有统计意义的发现。此外,研究表明,对小学儿童进行回顾性队列分析将消除与拒绝接种疫苗有关的伦理问题。结论:得出的结论是,确定的研究将有助于最大限度地提高疫苗接种依从性,并更好地告知澳大利亚政府有关疫苗接种的公共政策以及疫苗损害赔偿计划的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Vaccination and Autism: Evidence and Vaccine Compliance in Australia
Introduction: Australian Government health sites state that there is no link between vaccination and autism. These claims influence public health policy surrounding vaccination in Australia. Method: An examination of four Australian and one American Government sites was undertaken to identify original research articles examining the link between vaccination and autism. Claims concerning vaccination and autism are found to be based primarily on 23 original research articles. An analysis of relevant articles was made to see if a comparison between fully vaccinated (V) and completely unvaccinated (CUV) children was undertaken. Results: It is shown that none of the articles identified undertook a substantive comparison between V and CUV children. They do show that there is no significant difference in rates of autism in differently vaccinated groups of children, but without a comparison of V and CUV children they cannot make any final conclusions about a link between autism and vaccination. Discussion: To assess whether appropriate research can be undertaken to further examine any possible association between vaccination and autism, the numbers of unvaccinated children in ageappropriate cohorts in Australia are estimated. Sufficient numbers are found to permit statistically significant findings to be made. Further, it is shown that using a retrospective cohort based analysis of children at primary school will remove ethical issues relating to the denial of vaccination. Conclusion: It is concluded that the research identified will assist efforts to maximise vaccination compliance as well as better inform the Australia Government concerning public policy surrounding vaccination as well as the need for a vaccine damage compensation scheme.
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