{"title":"Gitelman综合征伴严重低钠血症和低钙血症1例报告","authors":"M. Abdulla, J. Alungal, S. Karumannil, R. Narayan","doi":"10.14740/WJNU149W","DOIUrl":null,"url":null,"abstract":"Gitelman syndrome (GS) is a recessive salt-losing tubulopathy due to a mutation of genes encoding the sodium chloride cotransporters and magnesium channels in the thiazide-sensitive segments of the distal convoluted tubule. In this paper we describe a 69-year-old lady with GS who presented with severe hyponatremia and hypocalcemia which are very rare complications associated with this syndrome. We are discussing the mechanisms involved in the development of these rare manifestations in this case report. World J Nephrol Urol. 2014;3(2):110-112 doi: http://dx.doi.o rg/10.14740/wjnu149 w","PeriodicalId":91634,"journal":{"name":"World journal of nephrology and urology","volume":"3 1","pages":"110-112"},"PeriodicalIF":0.0000,"publicationDate":"2014-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Severe Hyponatremia and Hypocalcemia in Gitelman Syndrome: A Case Report\",\"authors\":\"M. Abdulla, J. Alungal, S. Karumannil, R. Narayan\",\"doi\":\"10.14740/WJNU149W\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Gitelman syndrome (GS) is a recessive salt-losing tubulopathy due to a mutation of genes encoding the sodium chloride cotransporters and magnesium channels in the thiazide-sensitive segments of the distal convoluted tubule. In this paper we describe a 69-year-old lady with GS who presented with severe hyponatremia and hypocalcemia which are very rare complications associated with this syndrome. We are discussing the mechanisms involved in the development of these rare manifestations in this case report. World J Nephrol Urol. 2014;3(2):110-112 doi: http://dx.doi.o rg/10.14740/wjnu149 w\",\"PeriodicalId\":91634,\"journal\":{\"name\":\"World journal of nephrology and urology\",\"volume\":\"3 1\",\"pages\":\"110-112\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-05-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"World journal of nephrology and urology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14740/WJNU149W\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"World journal of nephrology and urology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14740/WJNU149W","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
摘要
Gitelman综合征(GS)是一种隐性失盐小管病，由于编码远曲小管中噻嗪类药物敏感段的氯化钠共转运体和镁通道的基因突变而引起。在本文中，我们描述了一位69岁的GS女士，她表现为严重的低钠血症和低钙血症，这是与该综合征相关的非常罕见的并发症。在本病例报告中，我们正在讨论这些罕见表现发展的机制。世界肾癌杂志，2014;3(2):110-112 doi: http://dx.doi.o rg/10.14740/wjnu149 w
Severe Hyponatremia and Hypocalcemia in Gitelman Syndrome: A Case Report
Gitelman syndrome (GS) is a recessive salt-losing tubulopathy due to a mutation of genes encoding the sodium chloride cotransporters and magnesium channels in the thiazide-sensitive segments of the distal convoluted tubule. In this paper we describe a 69-year-old lady with GS who presented with severe hyponatremia and hypocalcemia which are very rare complications associated with this syndrome. We are discussing the mechanisms involved in the development of these rare manifestations in this case report. World J Nephrol Urol. 2014;3(2):110-112 doi: http://dx.doi.o rg/10.14740/wjnu149 w
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