骨组织损伤填充剂刷石/聚乙二醇水泥的合成

Q3 Materials Science

Cerâmica Pub Date : 2021-09-01 DOI:10.1590/0366-69132021673833054

Otto Cumberbatch Morúa, M. Cardoso, H. N. D. Silva, R. Carrodeguas, Miguel A. Rodríguez, M. Fook

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引用次数: 3

摘要

摘要本研究的目的是在硅灰石/磷酸体系的基础上，掺入聚乙二醇(PEG)作为固化和加工添加剂，生产用于骨科应用的刷石水泥。通过溶解-沉淀法获得刷石/PEG水泥，并通过x射线衍射、抗压强度、孔隙率测定和生物行为(细胞粘附和生物活性测试)表征其理化性质。结果表明，形成的水泥土抗压强度为21.4 MPa，孔隙率为30%，与人的骨小梁相似。表面被证明是足够的细胞粘附和生长和生物活性与形成磷灰石层。聚乙二醇的掺入改善了工作条件，而不会引起所开发水泥的物理化学性质和生物行为的不良变化，因此有望修复骨组织损伤。

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Synthesis of brushite/polyethylene glycol cement for filler in bone tissue injuries

Abstract The objective of this work was to produce brushite cement for orthopedic applications, based on the system wollastonite/phosphoric acid with the incorporation of polyethylene glycol (PEG) as a setting and processing additive. Brushite/PEG cement was obtained by the dissolution-precipitation method and its physicochemical properties were characterized by X-ray diffraction, compressive strength, porosimetry, and biological behavior (cell adhesion and bioactivity tests). The results indicated the formation of brushite cement with 21.4 MPa of compressive strength and 30% porosity, similar to human trabecular bone. The surface was shown to be adequate for cell adhesion and growth and bioactive with the formation of apatite layers. The incorporation of PEG improved working conditions without causing undesirable changes in the physicochemical properties and biological behavior of developed cement, thus promising for the repair of bone tissue injuries.

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来源期刊

Cerâmica Materials Science-Ceramics and Composites

CiteScore

1.90

自引率

0.00%

发文量

审稿时长

10 weeks

期刊介绍： A Revista Cerâmica, órgão oficial da Associação Brasileira de Cerâmica (ABCERAM) publica contribuições originais de interesse na área de cerâmica, compreendendo arte cerâmica, abrasivos, biocerâmicas, cerâmicas avançadas, cerâmica branca, cerâmica de mesa, cerâmica eletroeletrônica, cerâmica estrutural, cerâmica magnética, cerâmica nuclear, cerâmica óptica, cerâmica química, cerâmica termomecânica, cerâmica vermelha, cimento, compósitos de matriz cerâmica, materiais refratários, materiais de revestimento, matérias-primas, vidrados, vidros e vitrocerâmicas, análise microestrutural, ciência básica, instrumentação, processos de fabricação, síntese de pós, técnicas de caracterização etc.