运动是否促进帕金森病的神经功能改变?初步临床研究

Q4 Medicine
F. Mendes, André Lucas Fidelis, Roberta D´Anna, G. Collura, M. Marrale, C. Gagliardo, Marco D´Amelio
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引用次数: 0

摘要

先前的研究已经证明了运动训练对帕金森病患者的有益作用。然而,据我们所知,没有一项研究评估过这些影响是否会因神经功能改变而持续。目的应用功能磁共振成像技术评价一种训练方法对帕金森病患者神经功能的影响。方法采用交叉设计的盲、随机、对照临床试验。参与者在WiiTM或控制训练前后接受了包括认知表现和功能磁共振成像的评估。培训为期10天,连续两周。从WiiTM训练开始的参与者随后被转移到对照组训练,反之亦然。训练之间有45天的淘汰期。结果两组患者的记忆、执行、视觉空间功能和注意功能较基线有显著改善(p < 0.05)。与对照组相比,在认知方面没有观察到差异。虽然不显著,但功能磁共振成像分析结果表明,WiiTM训练可以促进大脑功能连通性的改善,特别是在涉及运动执行、计划、视觉、记忆和体感功能的区域。结论:在帕金森病患者中,强化WiiTM训练可改善认知表现,强调认知加工相关区域的神经功能改变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Does exergaming promote neurofunctional changes in Parkinson´s disease? A pilot clinical study
Abstract Introduction Previous studies have demonstrated beneficial effects in people with Parkinson´s disease trained with exergames. However, to the best of our knowledge, none of them evaluated whether these effects are sustained by neurofunctional changes. Objective To evaluate neurofunctional effects of a training, by means of functional magnetic resonance imaging, in people with Parkinson´s disease. Methods This study was a blind, randomized, and controlled pilot clinical trial with crossover design. The participants were submitted to an evaluation including cognitive performance and functional magnetic resonance imaging before and after the WiiTM or control trainings. Trainings were applied for 10 days, in two consecutive weeks. Participants starting with WiiTM training were then moved to the control training and vice versa. A wash-out period of 45 days between the trainings was respected. Results Memory, executive and visuo-spatial functions, and attention were significantly improved compared to baseline (p < 0.05). No differences were observed in cognition compared to the control training. Though not significant, results of functional magnetic resonance imaging analyses suggested that WiiTM training could promote improvements on the brain functional connectivity especially in areas involved in motor execution, planning, visual, memory and somatosensory functions. Conclusion In people with Parkinson´s disease, an intensive WiiTM training improved cognitive performance that underlined neurofunctional changes in areas involved in cognitive processing.
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来源期刊
Fisioterapia em Movimento
Fisioterapia em Movimento Health Professions-Complementary and Manual Therapy
CiteScore
0.40
自引率
0.00%
发文量
78
审稿时长
13 weeks
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