茉莉酸甲酯对疏水离子液-介质两相培养体系生产紫杉醇及相关紫杉醇类化合物的影响

IF 0.6 4区工程技术 Q4 CHEMISTRY, MULTIDISCIPLINARY

Solvent Extraction Research and Development, Japan Pub Date : 2019-01-01 DOI:10.15261/SERDJ.26.105

Shinjiro Yamamoto, Fumiya Tabuchi, Rena Tanaka, S. Hayashi, H. Miyasaka

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引用次数: 0

摘要

我们在此报道了一种疏水离子液体(IL)， 1-丁基-1-甲基吡啶双(三氟甲磺酰基)亚胺(P14-TFSI)，它有助于在IL-培养基两相培养体系中原位提取紫杉醇和相关的10-去乙酰基baccatin III, baccatin III和头孢曼碱的紫杉醇烷的产量。在细胞培养体系中加入诱导子茉莉酸甲酯(MJ)，可提高含2.5% IL的培养液中紫杉烷的产量。含10 μM MJ和2.5 vol% IL的培养液中紫杉烷的总量是不含IL和MJ的对照培养液的200多倍，是仅含2.5 vol% IL培养液的2倍以上。

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Effect of Methyl Jasmonate on Production of Paclitaxel and Related Taxanes in a Hydrophobic Ionic Liquid-Medium Two Phase Culture System

We report here a hydrophobic ionic liquid (IL), 1-butyl-1-methylpyrrolidinium bis(trifluoromethanesulfonyl)imide (P14-TFSI), that contributed to increasing the amount of production of paclitaxel and the related taxanes of 10-deacetyl baccatin III, baccatin III and cepharomannine with in situ extraction from an aqueous medium in the IL-medium two phase culture system. Addition of an elicitor, methyl jasmonate (MJ) to the cell culture system enhanced the amount of production of the taxanes in the culture including 2.5 % IL. The total amount of the taxanes in the culture including 10 μM MJ and 2.5 vol% IL was more than 200 times greater than those in the control culture in the absence of IL and MJ, and more than two times greater than those in the culture including 2.5 vol% IL alone.

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来源期刊

Solvent Extraction Research and Development, Japan 工程技术-工程：化工

CiteScore

1.30

自引率

14.30%

发文量

审稿时长

1 months

期刊介绍： Solvent Extraction Research and Development, Japan (Solvent Extr. Res. Dev., Jpn.) is a periodical issued from Japan Association of Solvent Extraction (JASE) containing papers dealing with all aspects of solvent extraction and their related methods, underlying principles, and materials. Original articles, notes, technical reports, and critical reviews will be considered for publication. Original articles must be of reasonably broad scope and significance to the solvent extraction. Notes will originally describe novel work of a limited nature or especially significant work in progress. Authors can contribute some information of novel techniques, equipment or apparatus, reagents and diluents for solvent extraction as technical reports. Critical reviews will be received from the authors to whom the editorial committee asked to contribute.