静电纺PCL/丝素蛋白支架的制备与表征

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Emi Govorčin Bajsić, T. Grgurić, B. Mijović, I. Vrgoč Zimić, Tamara Dolenec, S. Kuzmić, Nikolina Mrkonjić, M. T. Trcin, I. Slivac, E. Zdraveva
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引用次数: 1

摘要

E.Govorčin Bajsić,a E.Zdraveva,b T.Holjevac Grgurić,c I.Slivac,d M.Tominac Trcin,E N.Mrkonjić,一个S.Kuzmić、f T.Dolenec、g I.VrgočZimić、g和b.Mijovićb,*萨格勒布大学化学工程与技术学院,Marulićev trg 19,10000萨格勒布,克罗地亚b萨格勒布本科纺织技术学院,Prilaz baruna Filipovića 28a,10000,克罗地亚c萨格勒布大学冶金学院,Aleja narodnih heroja 3,44000 Sisak,克罗地亚d萨格勒布本科食品技术和生物技术学院,Pierottijeva ul。克罗地亚萨格勒布6,10000 e免疫研究所,Rockefellerova 2,10000萨格勒布,克罗地亚法医科学中心“Ivan Vučetić
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Preparation and Characterization of Electrospun PCL/Silk Fibroin Scaffolds
Natural polymer-based scaffolds are generally considered as favourable matrices for the adhesion and growth of cells in tissue repair. One of the most popular materials in this respect is silk fibroin, known for its wide usage in biomedical applications. This work focuses on the development of electrospun scaffolds based on poly(ε-caprolactone) (PCL) and silk fibroin (SF) evaluated regarding the SF effect on their morphology, surface wetting ability, thermal properties, and HaCaT model cell line biocompatibility. The study revealed that the lowest PCL/SF concentration resulted in highest bead-like morphology formation, relatively thick fibers with the presence of random beads in the case of PCL, while uniform and thinner fibers in the case of increasing PCL/SF content scaffolds. The addition of SF reduced the degree of crystallinity in the PCL due to the less organized crystal structure, and decreased its thermal stability. Both SEM and MTT analyses showed cell presence on all scaffolds three days after cell seeding. Although SF improved PCL hydrophilicity, as shown quantitatively by the MTT assay for improved cytocompatibility properties, more structured electrospun PCL/SF scaffold strategies are required.
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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