膝关节置换术部位局部大疱性类天疱疮1例

Lucija Kosi, J. Perić, M. Pantović, G. Bijelic, Jelica Vukićević Sretenović, D. Škiljević
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引用次数: 5

摘要

局部大疱性类天疱疮是一种罕见的大疱性类天疱疮,其确切的发病机制尚不清楚。我们报告一例74岁的白人男性,在接受膝关节置换术9个月后出现了3个月的皮肤病变史。皮肤病学检查显示右膝上有几个瘙痒性紧张大疱,局限于手术疤痕周围,以及覆盖结痂的糜烂。局部大疱性类天疱疮的诊断通过直接免疫荧光试验(常规和裂皮)得到证实。患者接受了有效的局部类固醇治疗,这导致皮肤病变的完全解决。我们认为本例患者局部大疱性类天疱疮的发生可以用“免疫功能低下区”的概念来解释,其中一种疾病(手术)引起免疫改变,这是继发性疾病(如局部大疱性类天疱疮)发展的易感因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Localized Bullous Pemphigoid on the Site of Knee Arthroplasty: A Case Report
Abstract Localized bullous pemphigoid is a rare variant of bullous pemphigoid, and its exact etiopathogenesis is yet to be elucidated. We present a case of a 74-year-old Caucasian male with a 3-month history of skin lesions that appeared 9 months after he underwent a knee arthroplasty. Dermatological examination showed several pruritic tense bullae on the right knee, localized around the surgical scar, as well as erosions covered with crusts. The diagnosis of localized bullous pemphigoid was confirmed by direct immunofluorescence test (conventional and split-skin). The patient was treated with potent topical steroids, which led to complete resolution of cutaneous lesions. We suppose that the occurrence of localized bullous pemphigoid in our patient may be explained by the concept of “immunocompromised district” in which one disease (surgery) caused an immunological alteration which is a predisposing factor for the development of secondary disease such as localized bullous pemphigoid.
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期刊介绍: Serbian Journal of Dermatology and Venereology is a journal of the Serbian Association of Dermatologists and Venereologists. The journal is published in English, quarterly and intended to provide rapid publication of papers in the field of dermatology and venereology. Manuscripts are welcome from all countries in the following categories: editorials, original studies, review articles, professional articles, case reports, and history of medicine.
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