The effect of erythropoietin on phosphorus levels during hypoxia reoxygenation injury in rats

Abstract Background: The aim of this experimental study was to examine the effect of erythropoietin (Epo) in a rat model and particularly in a hypoxia-reoxygenation (HR) protocol. The beneficial effect or non-effectiveness of that molecule were studied biochemically using blood mean phosphorus (P) levels. Methods: Forty rats of mean weight 247.7 g were used in the study. P levels were measured at 60 min (groups A and C) and at 120 min (groups B and D) from reoxygenation. Epo was administered only in groups C and D. Results: Epo administration non-significantly increased P levels by 3.95%±3.35% (p=0.2100). Reperfusion time non-significantly decreased P levels by 0.35%±3.40% (p=0.9041). However, Epo administration and reperfusion time together produced a non-significant combined effect in increasing P levels by 2.45%±2.01% (p=0.2168). Conclusion: Epo administration, interacting or not with reperfusion time, has non-significant short-term increasing effects on P levels.