{"title":"microRNA195的生物学功能及其与血管生成的关系","authors":"Jingjing Wang, Q. Zeng, Caihong Yi, Jinjing Luo, Ningning Tang, Shao-Hua Wang, Jia Chen, K. Cao, Jianda Zhou","doi":"10.14800/RD.610","DOIUrl":null,"url":null,"abstract":"MicroRNA participates in multiple biological activities by combining with target genes, degrading target mRNA or suppressing its translation which regulates the expression of genes. MicroRNA-195 is an important member of microRNA-15/161/195/424/497 family. miRNA-195 exerts its significant biological function in regulating cell cycle, apoptosis, cell metabolism, cell proliferation and metastasis by targetedly modulating MYB, CCND1, CCND3, CCNE1, E2F3, CDK6, Bcl-2, APP, BACE1, GLUT, SRC-3, Vav2, and CDC42. Recent studies have shown that miRNA-195 regulates angiogenic factors such as FGF1, VEGF and signaling pathways such as TGF-β1/ Smads and that miRNA-195 participates in the restoration of intima, tumour, the remodling of angiocarpy.","PeriodicalId":90965,"journal":{"name":"RNA & disease (Houston, Tex.)","volume":"2 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2015-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"The biological function of microRNA195 and its relationship with angiogenesis\",\"authors\":\"Jingjing Wang, Q. Zeng, Caihong Yi, Jinjing Luo, Ningning Tang, Shao-Hua Wang, Jia Chen, K. Cao, Jianda Zhou\",\"doi\":\"10.14800/RD.610\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"MicroRNA participates in multiple biological activities by combining with target genes, degrading target mRNA or suppressing its translation which regulates the expression of genes. MicroRNA-195 is an important member of microRNA-15/161/195/424/497 family. miRNA-195 exerts its significant biological function in regulating cell cycle, apoptosis, cell metabolism, cell proliferation and metastasis by targetedly modulating MYB, CCND1, CCND3, CCNE1, E2F3, CDK6, Bcl-2, APP, BACE1, GLUT, SRC-3, Vav2, and CDC42. Recent studies have shown that miRNA-195 regulates angiogenic factors such as FGF1, VEGF and signaling pathways such as TGF-β1/ Smads and that miRNA-195 participates in the restoration of intima, tumour, the remodling of angiocarpy.\",\"PeriodicalId\":90965,\"journal\":{\"name\":\"RNA & disease (Houston, Tex.)\",\"volume\":\"2 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-02-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"RNA & disease (Houston, Tex.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14800/RD.610\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"RNA & disease (Houston, Tex.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14800/RD.610","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The biological function of microRNA195 and its relationship with angiogenesis
MicroRNA participates in multiple biological activities by combining with target genes, degrading target mRNA or suppressing its translation which regulates the expression of genes. MicroRNA-195 is an important member of microRNA-15/161/195/424/497 family. miRNA-195 exerts its significant biological function in regulating cell cycle, apoptosis, cell metabolism, cell proliferation and metastasis by targetedly modulating MYB, CCND1, CCND3, CCNE1, E2F3, CDK6, Bcl-2, APP, BACE1, GLUT, SRC-3, Vav2, and CDC42. Recent studies have shown that miRNA-195 regulates angiogenic factors such as FGF1, VEGF and signaling pathways such as TGF-β1/ Smads and that miRNA-195 participates in the restoration of intima, tumour, the remodling of angiocarpy.
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