天然骨粉增强PPF/HA纳米复合材料的生物物理性能

IF 1.9 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Advances in Materials Research-An International Journal Pub Date : 2015-09-25 DOI:10.12989/AMR.2015.4.3.145

N. A. Kamel, S. H. Mansour, S. Abd-El-Messieh, W. Khalil, K. N. A. Nour

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引用次数: 4

摘要

以富马酸聚丙烯(PPF)为不饱和聚酯制备了可生物降解和可注射的纳米复合材料。所研究的聚酯与三种不同的单体n -乙烯基吡喃烷酮(NVP)、甲基丙烯酸甲酯(MMA)和NVP与MMA的混合物(重量比为1:1)交联，填充45 wt%的羟基磷灰石(HA)，加入不同浓度的化学处理过的天然骨粉(NBP)(5)。10%和15%的重量%)，以便用于骨科骨病和骨折的治疗。将纳米复合材料浸泡在模拟体液(SBF)中30天，通过傅里叶变换红外(FTIR)、扫描电子显微镜(SEM)、能量色散x射线(EDX)以及介电测量研究了纳米复合材料的体外生物活性。研究了浸渍过程中样品的降解时间和SBF的pH值变化。

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Biophysical properties of PPF/HA nanocomposites reinforced with natural bone powder

Biodegredable and injectable nanocomposites based on polypropylene fumarate (PPF) as unsaturated polyester were prepared .The investigated polyester was crosslinked with three different monomers namely N-vinyl pyrrolidone (NVP), methyl methacrylate (MMA) and a mixture of NVP and MMA (1:1 weight ratio) and was filled with 45 wt% of hydroxyapatite (HA) incorporated with different concentrations of chemically treated natural bone powder (NBP) (5, 10 and 15 wt%) in order to be used in treatment of orthopedics bone diseases and fractures. The nanocomposites immersed in the simulated body fluid (SBF) for 30 days, after the period of immersion in-vitro bioactivity of the nanocomposites was studied through Fourier transform infrared (FTIR), scanning electron microscope (SEM), energy dispersive X-ray (EDX) in addition to dielectric measurements. The degradation time of immersed samples and the change in the pH of the SBF were studied during the period of immersion.

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来源期刊

Advances in Materials Research-An International Journal MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

3.50

自引率

27.30%

发文量