上皮细胞和树突状细胞在细菌处理中的相互作用

M. Rescigno, E. Mileti
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引用次数: 0

摘要

肠道菌群在免疫系统发育和正常功能中的作用越来越明显。在实验动物模型中,胃肠道微生物群的扰动或对该菌群的有害免疫反应已被证明在炎症性肠病(IBD)的发病机制中发挥关键作用,但最近也在肿瘤发生中发挥了关键作用。有人建议通过给IBD患者服用益生菌来改变肠道菌群。为了更好地了解益生菌如何对宿主有益,了解细菌如何在粘膜表面处理以及树突状细胞和上皮细胞如何相互沟通以“容忍”肠道菌群是很重要的。本文综述了近年来肠道免疫细胞功能的研究进展,以及一些益生菌菌株的免疫表型特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Interactions between Epithelial Cells and Dendritic Cells in Bacterial Handling
The role of the intestinal microflora in the development and correct functionality of the immune system is becoming increasingly evident. A perturbation of the gastrointestinal microflora or unwanted immune responses to this flora have been demonstrated to play a critical role in the pathogenesis of inflammatory bowel disease (IBD) in experimental animal models but recently also in tumorigenesis. It has been proposed to modify the intestinal microflora via the administration of probiotics in IBD patients. In order to better understand how probiotics could be beneficial to the host, it is important to understand how bacteria are handled at mucosal surfaces and how dendritic cells and epithelial cells communicate with each other to 'tolerate' the intestinal flora. This article is intended to summarize recent advances on the function of gut immune cells and on some of the features that have been documented on the immunophenotypic characteristics of some probiotic strains.
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