钙、镁离子辐照对羟基磷灰石生物活性和强度的影响

Q4 Engineering

Journal of Biomechanical Science and Engineering Pub Date : 2018-01-01 DOI:10.1299/JBSE.18-00036

Satoshi Kobayashi, Tomomi Izawa, Y. Teranishi, Yoshimi Ohyabu

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引用次数: 1

摘要

为了提高羟基磷灰石(HA)的生物活性，采用钙离子或镁离子辐照对羟基磷灰石表面进行改性。钙离子辐照可提高HA的生物活性，剂量可达10个离子/cm，而镁离子辐照对骨样磷灰石的形成没有影响。发现这种不同的现象归因于表面电位。离子辐照一般会引起表面纳米级损伤，但对HA的强度影响不显著。从细胞增殖情况看，钙离子辐照后的透明质酸没有毒性。以上结果证实了钙离子照射对HA治疗骨缺损的有效性。

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Effect of Ca or Mg ion irradiation on the bioactivity and strength of hydroxyapatite

In order to improve bioactivity of hydroxyapatite (HA), the surface of HA was modified with calcium or magnesium ion irradiation. Calcium ion irradiation improved bioactivity of HA up to ion dose 10 ions/cm, whereas magnesium ion irradiation did not affect bone-like apatite formation. It is found that this different phenomena were attributed to surface electrical potential. Ion irradiation generally induces surface nano-scopic damage, however the strength of HA was not significantly affected by ion irradiation. From cell proliferation, no toxicity of HA irradiated with calcium ions was confirmed. From these results, the effectiveness of calcium ion irradiation on the treatment of bone defect using HA is confirmed.

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来源期刊

Journal of Biomechanical Science and Engineering Engineering-Biomedical Engineering

CiteScore

0.90

自引率

0.00%

发文量