fk506及其类似物的神经生长潜力-大鼠对照试验的系统综述

IF 0.7 4区医学 Q Medicine

Plastic Surgery Pub Date : 2000-06-01 DOI:10.1177/229255030000800303

P. Nelluri, R. C. Lyons, A. Severo, D. Peterson, Uli K. Chettipally, Jamie R Garza

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引用次数: 2

摘要

背景:上肢神经损伤后很少能完全恢复损伤前的功能。神经修复延迟、神经间隙和局部缺血等因素被认为是其原因。在神经组织中存在神经营养因子的情况下，近端轴突段再生。fk506及其非免疫抑制类似物在实验中已被证明能影响轴突的生长。对动物和人类的平行研究表明，这些制剂具有强烈的毒性作用。目的系统回顾fk506及其类似物在大鼠周围神经再生中的随机对照试验资料。还审查了有关这些药剂毒性作用的报告。方法通过计算机检索1966年1月至1999年9月的MEDLINE文献和综述，检索词为“FK 506”、“FKBP-12配体”、“周围神经再生”和“FK 506的肾毒性、心脏毒性和神经毒性”。Tw……

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Nerve growth potential of FK 506 and its analogues - A systematic review of controlled trials in rats

BackgroundNerve injuries of the upper extremity seldom regain full preinjury function. Delay in nerve repair, nerve gap and ischemic local conditions are some of the factors attributed as the cause. The proximal axonal segment regenerates in the presence of neuronotrophic factors present in nerve tissue. FK 506 and its nonimmunosuppressive analogues have been shown to influence the growth of axons experimentally. Parallel studies of animals and human beings have demonstrated strong, toxic effects of these agents.PurposeTo review systematically data on the role of FK 506 and its analogues in peripheral nerve regeneration of randomized, controlled trials in rats. Reports dealing with the toxic effects of these agents all were reviewed as well.MethodsArticles and reviews were identified through a computerized search of MEDLINE from January 1966 to September 1999 by using the terms “FK 506”, “FKBP-12 ligands”, “peripheral nerve regeneration” and “nephrotoxicity, cardiotoxicity and neurotoxicity in FK 506”. Tw...

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来源期刊

Plastic Surgery SURGERY-

CiteScore

0.67

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Plastic Surgery (Chirurgie Plastique) is the official journal of the Canadian Society of Plastic Surgeons, the Canadian Society for Aesthetic Plastic Surgery, Group for the Advancement of Microsurgery, and the Canadian Society for Surgery of the Hand. It serves as a major venue for Canadian research, society guidelines, and continuing medical education.