冠状病毒免疫逃逸机制的研究进展

Q4 Pharmacology, Toxicology and Pharmaceutics

中国药科大学学报 Pub Date : 2021-01-01 DOI:10.11665/j.issn.1000-5048.20210101

R. Wang, Z. Zheng, Y. Zhang, R. Min, Y. Zhu, P. Zhang

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引用次数: 0

摘要

冠状病毒是人类和动物的重要病原体。其中，2019年爆发的新型冠状病毒病(COVID-19)给人类健康带来了致命威胁。宿主的先天免疫反应是宿主抵御病原体侵袭的第一道防线，但过度的免疫反应也会加重病毒感染和病理损伤。冠状病毒的免疫逃逸是导致死亡的重要致病机制。本文主要从宿主免疫传感器、干扰素、细胞因子、冠状病毒拮抗宿主免疫应答等几个方面综述冠状病毒免疫逃逸的致病机制，为抗冠状病毒药物的开发提供理论参考。

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Progress of research on immune escape mechanism of coronavirus

Coronavirus is an important pathogen of humans and animals.Among them, the novel coronavirus disease (COVID-19) breaking out in 2019 has brought a fatal threat to human health.The host's innate immune response is the host's first line of defense against pathogen invasion, but an excessive immune response can also aggravate viral infection and pathological damage.The immune escape of coronavirus is a critical pathogenic mechanism causing death.This work mainly reviews the pathogenic mechanism of coronavirus immune escape from several aspects such as host immunosensor, interferon, cytokine and coronavirus antagonizing host immune response, which provide a theoretical reference for the development of anti-coronavirus drugs.

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来源期刊

中国药科大学学报 Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.40

自引率

0.00%

发文量

6190

期刊介绍：