{"title":"脑啡肽降解酶抑制剂rb101对损伤大鼠坐骨神经功能恢复的影响","authors":"L. Kolosova, O. V. Riabchikova, A. Moisseeva","doi":"10.1163/092996397750131973","DOIUrl":null,"url":null,"abstract":"The effect of the systemically active inhibitor of enkephalin degrading enzymes (RB 101) on functional recovery of the rat sciatic nerve after transection and microsurgical suture was examined. Using the method of registration of compound action potentials (CAPs), the dose-dependent effect of RB 101 on regenerative processes in the nerve had been revealed. Both stimulating (at 100 μ g/kg and 1 mg/kg) and inhibitory (at 10 mg/kg) effects of RB 101 on the growth of regenerating nerve fibers were found after 20 days of surgical procedure. The role of opioids in the regulation of regenerative processes in peripheral nerves is discussed.","PeriodicalId":82360,"journal":{"name":"Primary sensory neuron : the international interdisciplinary journal reporting basic and clinical research on sensory receptors and primary afferent neurons","volume":"2 1","pages":"185-190"},"PeriodicalIF":0.0000,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1163/092996397750131973","citationCount":"0","resultStr":"{\"title\":\"The effect of enkephalin degrading enzymes inhibitor RB 101 on functional recovery of injured sciatic nerve of the rat\",\"authors\":\"L. Kolosova, O. V. Riabchikova, A. Moisseeva\",\"doi\":\"10.1163/092996397750131973\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The effect of the systemically active inhibitor of enkephalin degrading enzymes (RB 101) on functional recovery of the rat sciatic nerve after transection and microsurgical suture was examined. Using the method of registration of compound action potentials (CAPs), the dose-dependent effect of RB 101 on regenerative processes in the nerve had been revealed. Both stimulating (at 100 μ g/kg and 1 mg/kg) and inhibitory (at 10 mg/kg) effects of RB 101 on the growth of regenerating nerve fibers were found after 20 days of surgical procedure. The role of opioids in the regulation of regenerative processes in peripheral nerves is discussed.\",\"PeriodicalId\":82360,\"journal\":{\"name\":\"Primary sensory neuron : the international interdisciplinary journal reporting basic and clinical research on sensory receptors and primary afferent neurons\",\"volume\":\"2 1\",\"pages\":\"185-190\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1997-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1163/092996397750131973\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Primary sensory neuron : the international interdisciplinary journal reporting basic and clinical research on sensory receptors and primary afferent neurons\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1163/092996397750131973\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Primary sensory neuron : the international interdisciplinary journal reporting basic and clinical research on sensory receptors and primary afferent neurons","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1163/092996397750131973","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The effect of enkephalin degrading enzymes inhibitor RB 101 on functional recovery of injured sciatic nerve of the rat
The effect of the systemically active inhibitor of enkephalin degrading enzymes (RB 101) on functional recovery of the rat sciatic nerve after transection and microsurgical suture was examined. Using the method of registration of compound action potentials (CAPs), the dose-dependent effect of RB 101 on regenerative processes in the nerve had been revealed. Both stimulating (at 100 μ g/kg and 1 mg/kg) and inhibitory (at 10 mg/kg) effects of RB 101 on the growth of regenerating nerve fibers were found after 20 days of surgical procedure. The role of opioids in the regulation of regenerative processes in peripheral nerves is discussed.