兔下颌骨去卵巢后骨小梁的变化

T. Cao, T. Shirota, Y. Kamon, K. Ohno
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摘要

大量临床研究表明,绝经后女性口腔骨质流失风险增大可能与骨质疏松症有关。了解卵巢功能丧失动物无牙床骨的骨小梁变化可能有助于绝经后妇女种植牙的计划和治疗。本研究的目的是评价无牙铺垫骨在兔去卵巢植牙时的骨小梁变化。对12只成年雌性日本大白兔进行了检查。初步拔除下颚门牙,模拟无牙植牙的垫层骨。6只在拔牙12周后进行双侧卵巢切除,6只进行假卵巢切除。在卵巢切除或假卵巢切除12周后,对下颌远端体无牙部分进行未钙化处理,并进行定量骨小梁组织形态学测定。卵巢切除兔骨小梁分离、骨样体积、骨样厚度、骨样宽度、侵蚀面、矿物附着率显著增加,骨小梁数量显著减少。小梁结构稀疏、小梁类骨增多和小梁骨转换增加的结果表明,切除卵巢的家兔下颌无牙小梁骨丢失,并提示绝经后妇女也可能发生同样的丢失。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Trabecular Bone Changes in Ovariectomized Rabbit Mandibles
Numerous clinical studies have suggested that the greater risk for oral bone loss in females may be correlated with osteoporosis after menopause. Knowledge of trabecular changes in edentulous bedding bone in animals with loss of ovarian function may be beneficial in the planning and treating of dental implants in postmenopausal women. The purpose of this study was to evaluate trabeculae changes in edentulous bedding bone for dental implantation in ovariectomized rabbits. Twelve adult female Japanese white rabbits were examined. The mandibular incisors were initially extracted to simulate the edentulous bedding bone for dental implants. Six animals were bilaterally ovariectomized and the other 6 were sham-ovariectomized 12 weeks after tooth extraction. The edentulous parts of distal mandibular bodies were processed undecalcified 12 weeks after ovariectomy or sham-ovariectomy and examined by quantitative trabecular bone histomorphometry. In ovariectomized rabbits, there were significant increases in trabecular separation, osteoid volume, osteoid thickness, osteoid width, eroded surface, and mineral appositional rate, and a significant decrease in trabeculae number. The results of sparser trabecular structure, more trabecular osteoid, and increased trabecular bone turnover demonstrate bone loss of mandibular edentulous trabeculae in ovariectomized rabbits and suggest that the same loss may occur in postmenopausal women.
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