智人与秀丽隐杆线虫蛋白激酶亚家族紊乱区分析

Q2 Medicine

In Silico Biology Pub Date : 2010-02-15 DOI:10.1145/1722024.1722028

K. Kurup, J. Natarajan

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引用次数: 0

摘要

蛋白激酶是一种激酶酶，通过在其他蛋白质上添加磷酸基团来修饰它们。本研究首先对线虫和智人具有3个或3个以上共同结构域的蛋白激酶进行分组，并对每组蛋白激酶的紊乱区进行预测。然后发现了生物间无序区域的相似性。在这些相似的紊乱区域中存在线性基序，并对其在智人和秀丽隐杆线虫中的保守性进行了鉴定和测试。研究发现，尽管在这些远亲生物中，紊乱区域的相似性很高，但线性基序的保守性并不高。

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Analysis of disordered regions in protein kinase subfamilies of Homo sapiens and Coenorhabditis elegans

Protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them. In this work, first the protein kinases of Coenorhabditis elegans and Homo sapiens with three or more common domain were grouped and disorder regions of protein kinases in each group were predicted. Then the similarities of the disordered regions among the organisms were found. Linear motifs present in these similar disorder regions were identified and tested for their conservation in both Homo sapiens and Coenorhabditis elegans. It is found that, though the similarities in disorder regions are high, the linear motifs are not conserved much in these distantly related organisms.

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来源期刊

In Silico Biology Computer Science-Computational Theory and Mathematics

CiteScore

2.20

自引率

0.00%

发文量

期刊介绍： The considerable "algorithmic complexity" of biological systems requires a huge amount of detailed information for their complete description. Although far from being complete, the overwhelming quantity of small pieces of information gathered for all kind of biological systems at the molecular and cellular level requires computational tools to be adequately stored and interpreted. Interpretation of data means to abstract them as much as allowed to provide a systematic, an integrative view of biology. Most of the presently available scientific journals focus either on accumulating more data from elaborate experimental approaches, or on presenting new algorithms for the interpretation of these data. Both approaches are meritorious.