Psychopathology

50 to 200 per cent. above that of the control period. In four other cases the progress of the disease appeared arrested. No clinical improvement resulted in 13 patients, nine of whom were suffering from neuromuscular conditions in which increased creatinuria was absent or less than 50 per cent. above that of the control period. The result of these studies confirms the authors' view that both creatin and creatinin may have an exogenous origin from the amino-acids of the diet. Glycine therapy had little effect upon the distribution of nitrogen in the urine of three cases in the form of the total urea, ammonia, uric acid and undetermined nitrogen. The increase in creatin and creatinin excretion was affected in only one of these cases. Some evidence is presented that the lower motor neurone with the muscle it innervates must be functionally intact for creatin formation from amino-acids.