双氯芬酸钠对破骨细胞形成的影响

Q4 Pharmacology, Toxicology and Pharmaceutics

Oral Therapeutics and Pharmacology Pub Date : 2001-12-01 DOI:10.11263/JSOTP1982.20.196

M. Nobukawa, S. Yamada, H. Amano

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引用次数: 2

摘要

非甾体抗炎药(NSAIDs)是世界范围内最常用的一类药物。双氯芬酸钠是口腔医学中提倡使用的一种非甾体抗炎药。它还可以预防绝经后女性的骨质疏松症。本研究的目的是研究双氯芬酸钠对破骨细胞形成的可能抑制作用。非贴壁Sephadex g10通过的骨髓细胞在终浓度为15% FBS、60ng/mL RANKL、20ng/mL CSF-1的a-MEM中培养6天。双氯芬酸钠治疗体外剂量依赖性阻断破骨细胞生成。提示双氯芬酸钠可能直接作用于破骨细胞前体，预防骨质疏松。

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Effect of diclofenac sodium on osteoclast formation

Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used classes of medications worldwide. Diclofenac sodium is a kind of NSAIDs advocated for use in dental medicine. It is also well known to prevent osteoporosis in postmenopausal females. The purpose of the present study was to investigate the possible inhibitory effect on osteoclastogenesis in the presence of diclofenac sodium. Nonadherent Sephadex G10-passed bone marrow cells were cultured in a-MEM containing the final concentration of 15% FBS, 60ng/mL RANKL, 20ng/mL CSF-1 for 6 days. Treatment with diclofenac sodium blocked osteoclastogenesis in vitro dose-dependently. The results suggested that diclofenac sodium may act on the precursor of osteoclast directly to prevent osteoporosis.

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来源期刊

Oral Therapeutics and Pharmacology Medicine-Pharmacology (medical)

CiteScore

0.10

自引率

0.00%

发文量