干扰素的抗病毒活性。

Bacteriological Reviews Pub Date : 1977-09-01 DOI:10.1128/MMBR.41.3.543-567.1977

R. Friedman

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引用次数: 143

摘要

介绍 ..............................................................543年建立抗病毒的状态 ........... ....................544年干扰素绑定 ................... .............................544开发的抗病毒活性 .................................干扰素诱导的病毒生长抑制位点。547干扰素治疗抑制病毒脱壳的证据....... ...........干扰素治疗抑制病毒基因组转录的证据干扰素治疗抑制病毒蛋白合成的证据..... ......550年病毒感染细胞的观察 ...........................551颗粒系统的观察 ....... ....................552干扰素治疗抑制小鼠白血病病毒复制周期终止事件的证据........ .................557干扰素治疗在sv40基因组整合到干扰素耐药病毒或宿主基因组...........................的系统中无效559讨论.............................560篇文献引用...........................562

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Antiviral activity of interferons.

INTRODUCTION.............................................................. 543 ESTABLISHMENT OF THE ANTIVIRAL STATE ........... .................... 544 Interferon Binding ................... ............................. 544 Development of Antiviral Activity................................. 546 LOCUS OF THE INTERFERON-INDUCED INHIBITION OF VIRUS GROWTH. . 547 Evidence that Interferon Treatment Inhibits Virus Uncoating ....... ........... 547 Evidence that Interferon Treatment Inhibits Transcription of the Viral Genome. 547 Evidence that Interferon Treatment Inhibits Viral Protein Synthesis ..... ...... 550 Observations in virus-infected cells ........................... 551 Observations in cell-free systems ....... .................... 552 Evidence that Interferon Treatment Inhibits Terminal Events in the Replication Cycle of Murine Leukemia Viruses ........ ................. 557 INTERFERON TREATMENT IS INEFFECTIVE IN SYSTEMS IN WHICH THE SV40 GENOME IS INTEGRATED INTO AN INTERFERON-RESISTANT VIRUS OR A HOST GENOME ........................... 559 DISCUSSION ............................. 560 LITERATURE CITED........................... 562

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Bacteriological Reviews

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