MWCNTs对心肌收缩节律对ES-D3细胞三维培养分化的影响

Q4 Engineering

Nano Biomedicine Pub Date : 2014-01-01 DOI:10.11344/NANO.6.27

K. Imai, Tsubasa Shirai, F. Watari, T. Akasaka, T. Nishikawa, Tomoharu Okamura, A. Tanaka, K. Suese, Fumiya Ogawa, Y. Honda, H. Sawai, H. Takashima

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引用次数: 1

摘要

在生物材料中，纳米材料需要一个特殊的方案来检查其生物安全性。然而，目前还没有令人满意的安全评价方案。胚胎干细胞试验(EST)是一种已知的体外发育毒性试验方法[1-3]。我们已经使用EST方案检查了各种纳米材料的发育毒性[4-9]。我们之前报道了应用EST方案检测ES细胞二维培养中的MWCNTs和SWCNTs以及三维培养中的MWCNTs[4,7,8]。MWCNTs对心肌收缩节律对ES-D3细胞三维培养分化的影响

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Influence of MWCNTs to Myocardial Contraction Rhythms on Differentiation of ES-D3 Cells in Three-dimensional Culture

27 Introduction Among biomaterials, nanomaterials require a special protocol to examine their biological safety. However, no satisfactory protocol has been established for safety evaluation. The embryonic stem cell test (EST) is already known as an in vitro developmental toxicity test method [1-3]. We have examined the developmental toxicities of various nanomaterials using this EST protocol [4-9]. We previously reported the application of the EST protocol to examine MWCNTs and SWCNTs in two-dimensional culture and MWCNTs in the three-dimensional culture of ES cells [4, 7, 8]. Influence of MWCNTs to Myocardial Contraction Rhythms on Differentiation of ES-D3 Cells in Three-dimensional Culture

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来源期刊

Nano Biomedicine Engineering-Biomedical Engineering

CiteScore

0.30

自引率

0.00%

发文量