Is there a biochemical predictor of suicide?

There is a need for additional instruments to alert the clinician more effectively to the high self-destructive potential of some of his suicide-risk patients. In this study it was found that suicides-to-be tended to have higher plasma cortisols than suicidal patients who did not subsequently commit suicide within two years of the test. The article discusses the possible mechanisms involved and reviews some of the literature indicating that there may be a biochemical substratum that may play a significant role in some suicides.