A systematic review contrasting the administration of propofol for sedation of non-mechanically ventilated patients in non-critical care areas by anesthesia providers to that of non-anesthesia trained healthcare providers.

Review Questions/Objectives This systematic review seeks to synthesize the best available evidence on the administration of propofol for sedation by anesthesia providers and non-anesthesia trained providers of non-mechanically ventilated patients in non-critical care settings. Inclusion Criteria Types of participants This systematic review will consider non-anesthesia trained health care providers, and anesthesia providers administering propofol for sedation in non-critical care situations on (all adult and paediatric) patients who are not mechanically ventilated while undergoing gastrointestinal endoscopy, cardiac catheterization, and procedural sedation for emergency room and radiology procedures. Types of interventions The intervention of interest is the use of propofol sedation administered by non-anesthesia trained health care providers, and formally trained anesthesia providers for patients in non-critical care environments who were not mechanically ventilated while undergoing gastrointestinal endoscopies, cardiac catheterization, and procedural sedation for emergency room and radiology procedures. Types of outcome measures This systematic review will consider as outcomes: procedure time, return to baseline functioning, postoperative recovery time, mean amount of propofol administered, patient satisfaction, incidence of adverse hemodynamic and respiratory events, unplanned admission to hospital, and death of patients undergoing gastrointestinal endoscopy, cardiac catheterization, or procedural sedation for emergency room and radiology procedures while administering propofol for sedation. Adverse hemodynamic and respiratory events that will be considered are respiratory arrest, airway obstruction, hypoxia requiring intervention, hypotension, bradycardia, and arrhythmias.