HLA抗原在原发性高血压中的作用。与熟悉性格和血清免疫球蛋白有关。

B. Kristensen, P. Andersen, L. Lamm, F. Kissmeyer-Nielsen
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引用次数: 17

摘要

对149例原发性高血压患者进行hla分型,其中男性86例,女性63例。在66例血清免疫球蛋白水平显著升高的患者中,HLA-B27从对照组的8%增加到18% (P < 0.007)。当校正所分析抗原数量的p值时,这并不显着,但证实了该抗原与血清免疫球蛋白水平相关的报道。HLA-Bw15在有高血压家族史的患者(P校正小于0.05)和有自身抗体的患者中升高2倍(P校正小于0.05)。这与青少年糖尿病和系统性红斑狼疮中Bw15的增加有关,这些疾病也会发生血管损伤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
HLA antigens in essential hypertension. Relation to familiar disposition and serum immunoglobulins.
HLA-typing was performed in 149 patients with essential hypertension, 86 males and 63 females. In 66 patients with significantly elevated serum levels of immunoglobulins, HLA-B27 was increased to 18%, from 8% in the controls (P less than 0.007). This was not significant when correcting the P-value for the number of antigens analyzed, but confirms reports of an association of this antigen with serum levels of immunoglobulins. HLA-Bw15 was found to be increased two-fold in patients with a family history of hypertension (P corrected less than 0.05) and in patients with autoantibodies (not significant). This is discussed in relation to the increase of Bw15 in juvenile diabetes and in Systemic Lupus Erythematosus, diseases in which vascular damage also occurs.
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Tissue antigens
Tissue antigens 医学-病理学
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