一种基于文献的识别基因-疾病联系的方法

Proceedings. IEEE Computer Society Bioinformatics Conference Pub Date : 2002-08-14 DOI:10.1109/CSB.2002.1039334

Lada A. Adamic, Dennis M. Wilkinson, B. Huberman, Eytan Adar

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引用次数: 59

摘要

我们提出了一种统计方法，可以从文献中迅速识别出已知与特定疾病相关的基因集。它提供了一种综合处理别名符号的方法，一种计算基因与查询相关性的统计方法，以及一种消除基因符号与其他缩写歧义的新方法。这种方法通过发现与乳腺癌有关的基因得到了说明。

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A literature based method for identifying gene-disease connections

We present a statistical method that can swiftly identify, from the literature, sets of genes known to be associated with given diseases. It offers a comprehensive way to treat alias symbols, a statistical method for computing the relevance of the gene to the query, and a novel way to disambiguate gene symbols from other abbreviations. The method is illustrated by finding genes related to breast cancer.

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Proceedings. IEEE Computer Society Bioinformatics Conference

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