低压除颤在双域虚拟心室组织中的作用

O. Aslanidi, O. Mornev, A. Holden
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引用次数: 3

摘要

再入和除颤的终止机制仍然是一个挑战。利用虚拟心室组织的Luo-Rudy家族,我们模拟了周期性低压冲击下再入螺旋波的终止,研究了除颤的新机制。模拟的关键是扩展比多域组织表示,以解释外部浴槽(“三角域”)的存在,在那里施加冲击。带有浴槽的比多域模型再现了以前在实验中观察到的虚拟组织驻波中的周期性去极化模式。与经典的电极附近电压指数衰减相反,驻波在整个组织中传播,从而抵消了螺旋波。这种远场效应的机理是基于导电槽对外部施加电流的重新分配。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Low-voltage defibrillation in bidomain virtual ventricular tissue: effect of the bath
Mechanisms for termination of re-entry and defibrillation still remain a challenge. Using the Luo-Rudy family of virtual ventricular tissues we simulate termination of re-entrant spiral waves with a periodic low-voltage shock studying a new mechanism for defibrillation. Essential for the simulations is extension of the bidomain tissue representation in order to account for the existence of an external bath ("tridomain"), where the shock is applied The bidomain model with the bath reproduces periodic patterns of depolarization in the virtual tissue - standing waves, previously observed in experiments. In contrast to the classical exponential decay of voltage near the electrodes, standing waves entrain the whole tissue, thus canceling the spiral waves. The mechanism of this far-field effect is based on redistribution of the externally applied current by the conductive bath.
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