胰腺小细胞癌:原发性还是转移性?

IF 0.2
F. Mukhtar, J. Levesque, Shantel Hébert‐Magee, A. Nunez, I. Eltoum
{"title":"胰腺小细胞癌:原发性还是转移性?","authors":"F. Mukhtar, J. Levesque, Shantel Hébert‐Magee, A. Nunez, I. Eltoum","doi":"10.1097/PCR.0000000000000098","DOIUrl":null,"url":null,"abstract":"Background Primary small cell carcinoma (SCC) of the pancreas is rare, approximately 35 cases reported in the literature. The aim of this study was to review a large center experience with SCC and determine whether the tumor was primary or metastatic. Methods In this retrospective correlation study, we reviewed electronic medical records and cytology and histology reports of all endoscopic ultrasonography–guided fine-needle aspiration of the pancreas between 2000 and 2010 to identify cases diagnosed as SCC of the pancreas. We determined if lesions were primary or metastatic based on patient history, imaging, and pathologic findings. Metastasis was considered when the patient concurrently or previously had a mass elsewhere as well as immunohistochemical stains supporting the tumor origin. Results Two thousand four hundred forty-five pancreatic fine-needle aspirations were identified during the study period (2000–2010). One hundred thirty-four of 2445 cases were endocrine neoplasms, with 8 patients (6%) identified as SCC (poorly differentiated endocrine carcinoma). Five patients had primary lung carcinoma, and 1 patient had primary cervical SCC, whereas a primary lesion could not be identified in the other 2. The prevalence of SCC was 1.5% of all endocrine neoplasms. Cytologic features and endocrine markers were diagnostic of SCC in all patients. All but 1 patient died, survival ranging from 5 to 32 months (median, 11 months) after the diagnosis. Conclusions Pancreatic SCC is rare and carries a grave prognosis. Most pancreatic SCCs are metastatic; therefore, search for the primary tumor is required, particularly given recent reports of good response of primary SCC to surgical resection.","PeriodicalId":43475,"journal":{"name":"AJSP-Reviews and Reports","volume":"20 1","pages":"186–191"},"PeriodicalIF":0.2000,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/PCR.0000000000000098","citationCount":"0","resultStr":"{\"title\":\"Small Cell Carcinoma of the Pancreas: Primary or Metastatic?\",\"authors\":\"F. Mukhtar, J. Levesque, Shantel Hébert‐Magee, A. Nunez, I. Eltoum\",\"doi\":\"10.1097/PCR.0000000000000098\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background Primary small cell carcinoma (SCC) of the pancreas is rare, approximately 35 cases reported in the literature. The aim of this study was to review a large center experience with SCC and determine whether the tumor was primary or metastatic. Methods In this retrospective correlation study, we reviewed electronic medical records and cytology and histology reports of all endoscopic ultrasonography–guided fine-needle aspiration of the pancreas between 2000 and 2010 to identify cases diagnosed as SCC of the pancreas. We determined if lesions were primary or metastatic based on patient history, imaging, and pathologic findings. Metastasis was considered when the patient concurrently or previously had a mass elsewhere as well as immunohistochemical stains supporting the tumor origin. Results Two thousand four hundred forty-five pancreatic fine-needle aspirations were identified during the study period (2000–2010). One hundred thirty-four of 2445 cases were endocrine neoplasms, with 8 patients (6%) identified as SCC (poorly differentiated endocrine carcinoma). Five patients had primary lung carcinoma, and 1 patient had primary cervical SCC, whereas a primary lesion could not be identified in the other 2. The prevalence of SCC was 1.5% of all endocrine neoplasms. Cytologic features and endocrine markers were diagnostic of SCC in all patients. All but 1 patient died, survival ranging from 5 to 32 months (median, 11 months) after the diagnosis. Conclusions Pancreatic SCC is rare and carries a grave prognosis. Most pancreatic SCCs are metastatic; therefore, search for the primary tumor is required, particularly given recent reports of good response of primary SCC to surgical resection.\",\"PeriodicalId\":43475,\"journal\":{\"name\":\"AJSP-Reviews and Reports\",\"volume\":\"20 1\",\"pages\":\"186–191\"},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2015-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1097/PCR.0000000000000098\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"AJSP-Reviews and Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1097/PCR.0000000000000098\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"AJSP-Reviews and Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/PCR.0000000000000098","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

背景:原发性胰腺小细胞癌(SCC)是罕见的,文献报道的病例约为35例。本研究的目的是回顾一个大型中心的SCC经验,并确定肿瘤是原发的还是转移的。方法在本回顾性相关性研究中,我们回顾了2000年至2010年间所有超声内镜引导下的胰腺细针穿刺的电子病历、细胞学和组织学报告,以确定诊断为胰腺SCC的病例。我们根据患者病史、影像学和病理结果确定病变是原发性还是转移性。当患者同时或以前在其他地方有肿块以及免疫组织化学染色支持肿瘤起源时,考虑转移。结果2000-2010年共发现2445例胰腺细针穿刺。2445例中134例为内分泌肿瘤,其中8例(6%)为内分泌低分化癌(SCC)。5例患者为原发性肺癌,1例患者为原发性宫颈鳞状细胞癌,而另外2例患者未发现原发性病变。SCC的患病率占所有内分泌肿瘤的1.5%。所有患者的细胞学特征和内分泌标志物均可诊断SCC。除1例患者外,其余患者均死亡,诊断后生存期为5至32个月(中位11个月)。结论胰腺鳞状细胞癌罕见,预后严重。大多数胰腺SCCs是转移性的;因此,寻找原发肿瘤是必要的,特别是考虑到最近报道的原发性SCC对手术切除的良好反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Small Cell Carcinoma of the Pancreas: Primary or Metastatic?
Background Primary small cell carcinoma (SCC) of the pancreas is rare, approximately 35 cases reported in the literature. The aim of this study was to review a large center experience with SCC and determine whether the tumor was primary or metastatic. Methods In this retrospective correlation study, we reviewed electronic medical records and cytology and histology reports of all endoscopic ultrasonography–guided fine-needle aspiration of the pancreas between 2000 and 2010 to identify cases diagnosed as SCC of the pancreas. We determined if lesions were primary or metastatic based on patient history, imaging, and pathologic findings. Metastasis was considered when the patient concurrently or previously had a mass elsewhere as well as immunohistochemical stains supporting the tumor origin. Results Two thousand four hundred forty-five pancreatic fine-needle aspirations were identified during the study period (2000–2010). One hundred thirty-four of 2445 cases were endocrine neoplasms, with 8 patients (6%) identified as SCC (poorly differentiated endocrine carcinoma). Five patients had primary lung carcinoma, and 1 patient had primary cervical SCC, whereas a primary lesion could not be identified in the other 2. The prevalence of SCC was 1.5% of all endocrine neoplasms. Cytologic features and endocrine markers were diagnostic of SCC in all patients. All but 1 patient died, survival ranging from 5 to 32 months (median, 11 months) after the diagnosis. Conclusions Pancreatic SCC is rare and carries a grave prognosis. Most pancreatic SCCs are metastatic; therefore, search for the primary tumor is required, particularly given recent reports of good response of primary SCC to surgical resection.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊介绍: Each issue of Pathology Case Reviews examines one vital theme in the field with peer-reviewed, clinically oriented case reports that focus on diagnosis, specimen handling and reports generation. Each theme-oriented issue covers both histopathologic and cytopathologic cases, offering a comprehensive perspective that includes editorials and review articles of the newest developments in the field, differential diagnosis hints, applications of new technologies, reviews of current issues and techniques and an emphasis on new approaches.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信