外泌体衍生的miRNA在糖尿病伤口血管生成中的作用。

IF 3.5 2区 生物学 Q3 CELL BIOLOGY
Molecular and Cellular Biochemistry Pub Date : 2024-10-01 Epub Date: 2023-10-27 DOI:10.1007/s11010-023-04874-1
Wen-Ting Chen, Yi Luo, Xue-Mei Chen, Jian-Hui Xiao
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引用次数: 0

摘要

具有高度残疾的慢性伤口是糖尿病最常见和最严重的并发症之一。血管生成功能障碍损害糖尿病患者的伤口愈合。与只能提供症状治疗的传统疗法相比,干细胞由于其强大的旁分泌特性,可以缓解甚至治愈慢性糖尿病伤口的发病机制。外泌体衍生的微小RNA(miRNA)是干细胞旁分泌信号传导的重要组成部分,已被报道用于各种疾病模型的治疗,包括糖尿病伤口。外泌体衍生的miRNA已被广泛报道参与调节血管功能,并在皮肤伤口的修复和再生中具有良好的应用前景。因此,本文旨在综述外泌体衍生的miRNA在糖尿病诱导的伤口愈合损伤中的病理生理学现状,以及目前对其潜在机制的认识,强调血管生成的调控机制,希望为通过恢复糖尿病血管生成来改善伤口修复提供新的理论基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Role of exosome-derived miRNAs in diabetic wound angiogenesis.

Role of exosome-derived miRNAs in diabetic wound angiogenesis.

Chronic wounds with high disability are among the most common and serious complications of diabetes. Angiogenesis dysfunction impair wound healing in patients with diabetes. Compared with traditional therapies that can only provide symptomatic treatment, stem cells-owing to their powerful paracrine properties, can alleviate the pathogenesis of chronic diabetic wounds and even cure them. Exosome-derived microRNAs (miRNAs), important components of stem cell paracrine signaling, have been reported for therapeutic use in various disease models, including diabetic wounds. Exosome-derived miRNAs have been widely reported to be involved in regulating vascular function and have promising applications in the repair and regeneration of skin wounds. Therefore, this article aims to review the current status of the pathophysiology of exosome-derived miRNAs in the diabetes-induced impairment of wound healing, along with current knowledge of the underlying mechanisms, emphasizing the regulatory mechanism of angiogenesis, we hope to document the emerging theoretical basis for improving wound repair by restoring angiogenesis in diabetes.

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来源期刊
Molecular and Cellular Biochemistry
Molecular and Cellular Biochemistry 生物-细胞生物学
CiteScore
8.30
自引率
2.30%
发文量
293
审稿时长
1.7 months
期刊介绍: Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease publishes original research papers and short communications in all areas of the biochemical sciences, emphasizing novel findings relevant to the biochemical basis of cellular function and disease processes, as well as the mechanics of action of hormones and chemical agents. Coverage includes membrane transport, receptor mechanism, immune response, secretory processes, and cytoskeletal function, as well as biochemical structure-function relationships in the cell. In addition to the reports of original research, the journal publishes state of the art reviews. Specific subjects covered by Molecular and Cellular Biochemistry include cellular metabolism, cellular pathophysiology, enzymology, ion transport, lipid biochemistry, membrane biochemistry, molecular biology, nuclear structure and function, and protein chemistry.
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