衰老对大鼠胫骨前肌基底膜损伤恢复期的影响

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-03-29 DOI:10.1093/jmicro/dfac016

Yuji Kanazawa, M. Nagano, S. Koinuma, S. Sugiyo, Y. Shigeyoshi

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引用次数: 3

摘要

摘要研究损伤后肌肉恢复过程中衰老对基底膜(BM)的影响。通过大鼠模型，我们发现衰老延迟了肌纤维和脑基恢复。此外，无论是年轻大鼠还是老年大鼠，在肌肉损伤后7天，脑损伤相关因子的表达均达到峰值。胶原合成因子的峰值表达随年龄的增长而降低，而降解因子的表达不受年龄的影响。这些结果表明，损伤后肌纤维和BM恢复的年龄相关延迟可能与胶原合成因子的抑制有关。

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Effects of aging on basement membrane of tibialis anterior muscle during recovery following muscle injury in rats

Abstract We investigated the effect of aging on the basement membrane (BM) during postinjury muscle recovery. Using a rat model, we found that aging delayed muscle fiber and BM recovery. In addition, expression of BM-related factors peaked 7 days after muscle injury among both young and older rats. Peak expression of collagen IV synthetic factors decreased with age, whereas expression of the degradative factor was unaffected by age. These results suggest that age-related delays in postinjury muscle fiber and BM recovery may be related to the suppression of collagen IV synthetic factors.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.