Palliative radiation in advanced cancer patients with symptomatic bone metastases

ABSTRACT Introduction: Bone metastases are a frequent complication of advanced cancer, the most common cause of cancer-related pain and a source of significant morbidity and mortality. Optimal management can reduce skeletal-related events and improve quality of life. Areas covered: This article reviews the indications, treatment regimens and outcomes of palliative radiotherapy (RT) for symptomatic complicated and uncomplicated bone metastases, including pain, function and quality of life. Expert commentary: Patients with a limited number of bone metastases, termed ‘oligometastases’, may be candidates for a stereotactic ablative approach. For the majority, however, conventional external beam radiotherapy is the mainstay of non-invasive treatment. In concert with a multi-disciplinary management approach, RT reduces pain and improves function and quality of life.