The First Case of Paraphilia Treated With Depo-Provera: 40-Year Outcome

The first male ever to receive treatment with the antiandrogenic hormone medroxyprogesterone acetate (MPA, Depo-Provera) for paraphilic pathology is now 65 years old, and has been in sporadic, self-demand follow-up for 40 years. His sexological history has included, progressively, paraphilic cross-dressing, gay bashing, gay and straight brief encounters, long-lasting heterosexual monogamy, 2 episodes of genital fondling of his juvenile son, and prolonged paraphilic infantilism. Depo-Provera permitted the cessation of illicit sexual activity, but did not eradicate paraphilic sexopathology in toto.