审查问题

Seminars in vascular medicine Pub Date : 2005-05-01 DOI:10.1055/s-2005-872408

M. Jan Jacques Michiels, Ph.D. Guest Robert, Yvo Clarke M.D., Ph.D. Brian Smulders, Ph.D Coen D.A Fowler, M. D. Stehouwer

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摘要

8. 为什么MTHFR 677C >t (Alanine222Valine)多态性是同型半胱氨酸水平的重要决定因素?答:因为多态性降低MTHFR活性，增加同型半胱氨酸，特别是在叶酸水平低的情况下。B.因为多态性使得MTHFR酶更容易受到温度小幅升高的影响。C.因为多态性损害了FAD的结合，而FAD是MTHFR的辅助因子。

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Review Questions

8. Why is the MTHFR 677C>T (Alanine222Valine) polymorphism such an important determinant of homocysteine levels? A. Because the polymorphism reduces MTHFR activity and increases homocysteine, especially at low folate status. B. Because the polymorphism makes the MTHFR enzyme more vulnerable to small increases in temperature. C. Because the polymorphism impairs binding of FAD, which is the cofactor of MTHFR.

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Seminars in vascular medicine

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