下颌髁中央巨细胞肉芽肿:新增病例及文献回顾

Q3 Dentistry
L. Marti-Flich, M. Schlund, R. Nicot
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引用次数: 1

摘要

颌骨中央巨细胞肉芽肿(CGCG)是一种不常见的病变。只有5例报告在下颌髁。观察:一个25岁的男性表现为耳前肿胀和磨牙过早咬合接触。病变具有侵袭性和高代谢摄取的影像学特征。最初的活检具有误导性。病变通过手术切除治疗。讨论:组织学上,CGCG与其他巨细胞病变如GCT(巨细胞瘤)或BTH(甲状旁腺功能亢进棕色肿瘤)非常相似。标准的治疗方法是手术刮除或切除。文献中只报道了6例,包括这一例。诊断是困难的,依靠一束临床,放射学和组织学的论点。但为避免肿瘤复发,应进行根治性手术。与CGCG相关的基因突变(特别是TRPV4和RAS通路)可能解释了为什么这种肿瘤主要发生在颌骨的牙齿部分,而很少发生在下颌髁。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Central giant cell granuloma of the mandibular condyle: additional case and literature review
Introduction: Central giant cell granuloma (CGCG) of the jaws is not a common lesion. Only five cases are reported in the mandibular condyle. Observation: A 25 year-old male presented with preauricular swelling and a premature occlusal contact on the molars. The lesion had radiological features of aggressiveness and a high metabolic uptake. Initial biopsy was misleading. The lesion was treated surgically by resection. Discussion: Histologically, CGCG are very similar to other giant cell lesions such as GCT (Giant cell Tumor) or BTH (brown tumor of hyperparathyroidism). The standard treatment is surgical either by curettage or resection. Only 6 cases have been described in the literature, including this one. The diagnosis is difficult, relying on a bundle of clinical, radiological and histological arguments. However, radical surgery should be performed to avoid the tumor recurrence. The genetic mutations associated with CGCG (notably TRPV4 and RAS pathway) may explain why this tumor is mostly found in the dental part of the jaws and only rarely in the mandibular condyle.
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来源期刊
Journal of Oral Medicine and Oral Surgery
Journal of Oral Medicine and Oral Surgery Dentistry-Dentistry (miscellaneous)
CiteScore
0.80
自引率
0.00%
发文量
21
审稿时长
24 weeks
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