表观遗传编程与胎儿生长限制

J. Ferreira, S. Choufani, J. Kingdom, R. Weksberg
{"title":"表观遗传编程与胎儿生长限制","authors":"J. Ferreira, S. Choufani, J. Kingdom, R. Weksberg","doi":"10.1017/S0965539510000057","DOIUrl":null,"url":null,"abstract":"Normal fetal growth and development depends on multiple molecular mechanisms that coordinate both placental and fetal development. Efforts to better understand fetal/placental growth dysregulation and fetal growth restriction (FGR) are now being driven by several findings that highlight the longterm impact of FGR on susceptibility to disease. The association of poor fetal growth to perinatal medical complications is well accepted but more recent data also show that FGR is linked to common, serious adult health problems. Several large-scale human epidemiological studies from diverse countries have shown that conditions such as coronary heart disease, hypertension, stroke, type 2 diabetes mellitus, adiposity, insulin resistance and osteoporosis are more prevalent in individuals with a history of low birthweight.","PeriodicalId":89369,"journal":{"name":"Fetal and maternal medicine review","volume":"21 1","pages":"204-224"},"PeriodicalIF":0.0000,"publicationDate":"2010-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S0965539510000057","citationCount":"2","resultStr":"{\"title\":\"EPIGENETIC PROGRAMMING AND FETAL GROWTH RESTRICTIONS\",\"authors\":\"J. Ferreira, S. Choufani, J. Kingdom, R. Weksberg\",\"doi\":\"10.1017/S0965539510000057\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Normal fetal growth and development depends on multiple molecular mechanisms that coordinate both placental and fetal development. Efforts to better understand fetal/placental growth dysregulation and fetal growth restriction (FGR) are now being driven by several findings that highlight the longterm impact of FGR on susceptibility to disease. The association of poor fetal growth to perinatal medical complications is well accepted but more recent data also show that FGR is linked to common, serious adult health problems. Several large-scale human epidemiological studies from diverse countries have shown that conditions such as coronary heart disease, hypertension, stroke, type 2 diabetes mellitus, adiposity, insulin resistance and osteoporosis are more prevalent in individuals with a history of low birthweight.\",\"PeriodicalId\":89369,\"journal\":{\"name\":\"Fetal and maternal medicine review\",\"volume\":\"21 1\",\"pages\":\"204-224\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1017/S0965539510000057\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Fetal and maternal medicine review\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1017/S0965539510000057\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fetal and maternal medicine review","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1017/S0965539510000057","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2

摘要

正常的胎儿生长发育依赖于协调胎盘和胎儿发育的多种分子机制。一些研究结果强调了胎儿生长受限(FGR)对疾病易感性的长期影响,这推动了人们更好地理解胎儿/胎盘生长失调和胎儿生长受限(FGR)的努力。胎儿生长不良与围产期医学并发症之间的联系已被广泛接受,但最近的数据也表明,FGR与常见的严重成人健康问题有关。来自不同国家的几项大规模人类流行病学研究表明,冠心病、高血压、中风、2型糖尿病、肥胖、胰岛素抵抗和骨质疏松症等疾病在有低出生体重史的个体中更为普遍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
EPIGENETIC PROGRAMMING AND FETAL GROWTH RESTRICTIONS
Normal fetal growth and development depends on multiple molecular mechanisms that coordinate both placental and fetal development. Efforts to better understand fetal/placental growth dysregulation and fetal growth restriction (FGR) are now being driven by several findings that highlight the longterm impact of FGR on susceptibility to disease. The association of poor fetal growth to perinatal medical complications is well accepted but more recent data also show that FGR is linked to common, serious adult health problems. Several large-scale human epidemiological studies from diverse countries have shown that conditions such as coronary heart disease, hypertension, stroke, type 2 diabetes mellitus, adiposity, insulin resistance and osteoporosis are more prevalent in individuals with a history of low birthweight.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信