{"title":"树突状细胞对免疫的调节","authors":"Nina Bhardwaj M.D., Ph.D.","doi":"10.1016/S1529-1049(02)00159-9","DOIUrl":null,"url":null,"abstract":"<div><p>T cell immunity is initiated by specialized antigen presenting cells known as dendritic cells (DCs). Antigen-pulsed DCs have been used to induce anti-tumor T cell and clinical responses in humans, apparently without significant toxicity. Under certain conditions, DCs even silence T cell immune responses in vivo. Therefore, DCs may be valuable tools for modulating immunity in the setting of autoimmunity, cancer, and chronic viral infections.</p></div>","PeriodicalId":89340,"journal":{"name":"Clinical and applied immunology reviews","volume":"3 4","pages":"Pages 173-182"},"PeriodicalIF":0.0000,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1529-1049(02)00159-9","citationCount":"3","resultStr":"{\"title\":\"The modulation of immunity by dendritic cells\",\"authors\":\"Nina Bhardwaj M.D., Ph.D.\",\"doi\":\"10.1016/S1529-1049(02)00159-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>T cell immunity is initiated by specialized antigen presenting cells known as dendritic cells (DCs). Antigen-pulsed DCs have been used to induce anti-tumor T cell and clinical responses in humans, apparently without significant toxicity. Under certain conditions, DCs even silence T cell immune responses in vivo. Therefore, DCs may be valuable tools for modulating immunity in the setting of autoimmunity, cancer, and chronic viral infections.</p></div>\",\"PeriodicalId\":89340,\"journal\":{\"name\":\"Clinical and applied immunology reviews\",\"volume\":\"3 4\",\"pages\":\"Pages 173-182\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2003-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S1529-1049(02)00159-9\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical and applied immunology reviews\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1529104902001599\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and applied immunology reviews","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1529104902001599","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
T cell immunity is initiated by specialized antigen presenting cells known as dendritic cells (DCs). Antigen-pulsed DCs have been used to induce anti-tumor T cell and clinical responses in humans, apparently without significant toxicity. Under certain conditions, DCs even silence T cell immune responses in vivo. Therefore, DCs may be valuable tools for modulating immunity in the setting of autoimmunity, cancer, and chronic viral infections.
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