E. Reyna-Villasmil, D. Torres-Cepeda, J. Santos-Bolívar, J. Mejia-Montilla, N. Reyna-Villasmil, A. Fernández-Ramírez
{"title":"异前列腺素-8在子痫前期和子痫中的血浆浓度","authors":"E. Reyna-Villasmil, D. Torres-Cepeda, J. Santos-Bolívar, J. Mejia-Montilla, N. Reyna-Villasmil, A. Fernández-Ramírez","doi":"10.1016/j.rprh.2016.10.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>To compare plasma vascular 8-isoprostane concentrations in pregnant women with pre-eclampsia and eclampsia.</p></div><div><h3>Material and methods</h3><p>Patients attending the Hospital Central Dr. Urquinaona in Maracaibo, Venezuela, were selected. The study included 30 patients with mild pre-eclampsia (group A), 30 patients with severe pre-eclampsia (group B), and 30 patients with eclampsia (group C). A control group was also included, consisting of 30 healthy pregnant women (group D) of similar age and body mass index to studied groups. Only nulliparous patients were included. Plasma samples were collected for the 8-isoprostane determination from all patients before delivery, and in the studied groups immediately after diagnosis.</p></div><div><h3>Results</h3><p>Statistically significant differences were found in gestational age between groups B and C compared with the control group (p<!--> <!--><<!--> <!-->.05). Higher values of plasma 8-isoprostane were observed in severe pre-eclampsia patients (366.0<!--> <!-->±<!--> <!-->29.7<!--> <!-->pg/mL), as well as in eclampsia patients (354.2<!--> <!-->±<!--> <!-->26.9<!--> <!-->pg/mL). Lower values were found in mild pre-eclampsia patients (302.2<!--> <!-->±<!--> <!-->31.6<!--> <!-->pg/mL). The studied groups had significantly higher values of plasma 8-isoprostane compared with controls (209.3<!--> <!-->±<!--> <!-->19.1<!--> <!-->pg/mL; p<!--> <!--><<!--> <!-->.05). Linear regression analysis found that the factor that was significantly associated with 8-isoprostane concentrations was the 24-h urine protein level (p<!--> <!--><<!--> <!-->.05).</p></div><div><h3>Conclusion</h3><p>Eclampsia and pre-eclampsia patients had higher plasma 8-isoprostane concentrations than healthy normotensive pregnant women.</p></div>","PeriodicalId":32275,"journal":{"name":"Perinatologia y Reproduccion Humana","volume":"30 4","pages":"Pages 180-185"},"PeriodicalIF":0.0000,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rprh.2016.10.001","citationCount":"1","resultStr":"{\"title\":\"Concentraciones plasmáticas de isoprostano-8 en preeclampsia y eclampsia\",\"authors\":\"E. Reyna-Villasmil, D. Torres-Cepeda, J. Santos-Bolívar, J. Mejia-Montilla, N. Reyna-Villasmil, A. Fernández-Ramírez\",\"doi\":\"10.1016/j.rprh.2016.10.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>To compare plasma vascular 8-isoprostane concentrations in pregnant women with pre-eclampsia and eclampsia.</p></div><div><h3>Material and methods</h3><p>Patients attending the Hospital Central Dr. Urquinaona in Maracaibo, Venezuela, were selected. The study included 30 patients with mild pre-eclampsia (group A), 30 patients with severe pre-eclampsia (group B), and 30 patients with eclampsia (group C). A control group was also included, consisting of 30 healthy pregnant women (group D) of similar age and body mass index to studied groups. Only nulliparous patients were included. Plasma samples were collected for the 8-isoprostane determination from all patients before delivery, and in the studied groups immediately after diagnosis.</p></div><div><h3>Results</h3><p>Statistically significant differences were found in gestational age between groups B and C compared with the control group (p<!--> <!--><<!--> <!-->.05). Higher values of plasma 8-isoprostane were observed in severe pre-eclampsia patients (366.0<!--> <!-->±<!--> <!-->29.7<!--> <!-->pg/mL), as well as in eclampsia patients (354.2<!--> <!-->±<!--> <!-->26.9<!--> <!-->pg/mL). Lower values were found in mild pre-eclampsia patients (302.2<!--> <!-->±<!--> <!-->31.6<!--> <!-->pg/mL). The studied groups had significantly higher values of plasma 8-isoprostane compared with controls (209.3<!--> <!-->±<!--> <!-->19.1<!--> <!-->pg/mL; p<!--> <!--><<!--> <!-->.05). Linear regression analysis found that the factor that was significantly associated with 8-isoprostane concentrations was the 24-h urine protein level (p<!--> <!--><<!--> <!-->.05).</p></div><div><h3>Conclusion</h3><p>Eclampsia and pre-eclampsia patients had higher plasma 8-isoprostane concentrations than healthy normotensive pregnant women.</p></div>\",\"PeriodicalId\":32275,\"journal\":{\"name\":\"Perinatologia y Reproduccion Humana\",\"volume\":\"30 4\",\"pages\":\"Pages 180-185\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.rprh.2016.10.001\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Perinatologia y Reproduccion Humana\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0187533717300079\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Perinatologia y Reproduccion Humana","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0187533717300079","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Concentraciones plasmáticas de isoprostano-8 en preeclampsia y eclampsia
Objective
To compare plasma vascular 8-isoprostane concentrations in pregnant women with pre-eclampsia and eclampsia.
Material and methods
Patients attending the Hospital Central Dr. Urquinaona in Maracaibo, Venezuela, were selected. The study included 30 patients with mild pre-eclampsia (group A), 30 patients with severe pre-eclampsia (group B), and 30 patients with eclampsia (group C). A control group was also included, consisting of 30 healthy pregnant women (group D) of similar age and body mass index to studied groups. Only nulliparous patients were included. Plasma samples were collected for the 8-isoprostane determination from all patients before delivery, and in the studied groups immediately after diagnosis.
Results
Statistically significant differences were found in gestational age between groups B and C compared with the control group (p < .05). Higher values of plasma 8-isoprostane were observed in severe pre-eclampsia patients (366.0 ± 29.7 pg/mL), as well as in eclampsia patients (354.2 ± 26.9 pg/mL). Lower values were found in mild pre-eclampsia patients (302.2 ± 31.6 pg/mL). The studied groups had significantly higher values of plasma 8-isoprostane compared with controls (209.3 ± 19.1 pg/mL; p < .05). Linear regression analysis found that the factor that was significantly associated with 8-isoprostane concentrations was the 24-h urine protein level (p < .05).
Conclusion
Eclampsia and pre-eclampsia patients had higher plasma 8-isoprostane concentrations than healthy normotensive pregnant women.
期刊介绍：
Perinatología y Reproducción Humana is the official journal of the Instituto Nacional de Perinatología, Mexico. It is aimed at physicians of the area of perinatal and reproductive health (obstetrics and gynecology, maternal and fetal medicine, pediatricians, neonatologists, endocrinologists, infectious disease specialists, and neurologists) and also at health sciences professionals involved in the study of reproduction perinatal and reproductive health (chemists, biologists and neuro-physiologists). It is an electronic biannual journal, that publishes peer-reviewed original articles, in-deep reviews, letters to the editor and special sections related to basic, epidemiological, surgical, and clinical aspects in the area of perinatal and reproductive health, in English or Spanish languages and open access.
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