{"title":"秀丽隐杆线虫抗衰老化合物及其靶点研究进展","authors":"Eun Ji E. Kim, Seung-Jae V. Lee","doi":"10.1016/j.tma.2019.11.003","DOIUrl":null,"url":null,"abstract":"<div><p>Searching for drugs that extend healthy lifespan and the subsequent analysis of their mechanisms of action is a crucial aspect for aging research. However, identifying both longevity-enhancing drugs and their corresponding targets is challenging. The roundworm <em>Caenorhabditis elegans</em> is a suitable model for such research because of its short lifespan and genetic tractability. In this perspective, we discuss recent progresses on the identification of anti-aging drugs and characterization of their targets using <em>C. elegans</em> as a model organism. In particular, minocycline, JZL184, monorden, and paxilline increase <em>C. elegans</em> lifespan by inhibiting 18S rRNA/ribosome, fatty acid amide hydrolase-4, Hsp90, and the Ca<sup>2+</sup>-activated K<sup>+</sup> (BK) channel SLO-1, respectively. Because many factors that regulate aging and lifespan in <em>C. elegans</em> are evolutionarily conserved, these newly identified lifespan-extending compounds may guide the development of anti-aging medicines for humans.</p></div>","PeriodicalId":36555,"journal":{"name":"Translational Medicine of Aging","volume":"3 ","pages":"Pages 121-124"},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tma.2019.11.003","citationCount":"11","resultStr":"{\"title\":\"Recent progresses on anti-aging compounds and their targets in Caenorhabditis elegans\",\"authors\":\"Eun Ji E. Kim, Seung-Jae V. Lee\",\"doi\":\"10.1016/j.tma.2019.11.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Searching for drugs that extend healthy lifespan and the subsequent analysis of their mechanisms of action is a crucial aspect for aging research. However, identifying both longevity-enhancing drugs and their corresponding targets is challenging. The roundworm <em>Caenorhabditis elegans</em> is a suitable model for such research because of its short lifespan and genetic tractability. In this perspective, we discuss recent progresses on the identification of anti-aging drugs and characterization of their targets using <em>C. elegans</em> as a model organism. In particular, minocycline, JZL184, monorden, and paxilline increase <em>C. elegans</em> lifespan by inhibiting 18S rRNA/ribosome, fatty acid amide hydrolase-4, Hsp90, and the Ca<sup>2+</sup>-activated K<sup>+</sup> (BK) channel SLO-1, respectively. Because many factors that regulate aging and lifespan in <em>C. elegans</em> are evolutionarily conserved, these newly identified lifespan-extending compounds may guide the development of anti-aging medicines for humans.</p></div>\",\"PeriodicalId\":36555,\"journal\":{\"name\":\"Translational Medicine of Aging\",\"volume\":\"3 \",\"pages\":\"Pages 121-124\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.tma.2019.11.003\",\"citationCount\":\"11\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Translational Medicine of Aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2468501119300410\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational Medicine of Aging","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468501119300410","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
Recent progresses on anti-aging compounds and their targets in Caenorhabditis elegans
Searching for drugs that extend healthy lifespan and the subsequent analysis of their mechanisms of action is a crucial aspect for aging research. However, identifying both longevity-enhancing drugs and their corresponding targets is challenging. The roundworm Caenorhabditis elegans is a suitable model for such research because of its short lifespan and genetic tractability. In this perspective, we discuss recent progresses on the identification of anti-aging drugs and characterization of their targets using C. elegans as a model organism. In particular, minocycline, JZL184, monorden, and paxilline increase C. elegans lifespan by inhibiting 18S rRNA/ribosome, fatty acid amide hydrolase-4, Hsp90, and the Ca2+-activated K+ (BK) channel SLO-1, respectively. Because many factors that regulate aging and lifespan in C. elegans are evolutionarily conserved, these newly identified lifespan-extending compounds may guide the development of anti-aging medicines for humans.
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