靶向衰老细胞的纳米载体

Q2 Medicine

Translational Medicine of Aging Pub Date : 2019-01-01 DOI:10.1016/j.tma.2019.01.001

Daniel Muñoz-Espín

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引用次数: 15

摘要

衰老和人类多种慢性疾病与衰老细胞在多种组织中的异常积累有关，衰老细胞导致器官功能障碍并驱动其病理表现。在临床前小鼠模型中，消除衰老细胞可以改善甚至逆转年龄相关疾病的进展，从而延长健康寿命和寿命。针对衰老细胞的递送载体的开发为转化医学提供了创新的治疗和诊断应用。

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Nanocarriers targeting senescent cells

Ageing and multiple chronic diseases in humans associate with an aberrant accumulation of senescent cells in a diversity of tissues, which contributes to organ dysfunction and drives their pathological manifestations. It emerges that elimination of senescent cells ameliorates and even reverts the progression of age-related disorders, thereby extending healthspan and lifespan in preclinical mouse models. Development of delivery carriers specifically targeting senescent cells offers innovative therapeutic and diagnostic applications in translational medicine.

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来源期刊

Translational Medicine of Aging Medicine-Geriatrics and Gerontology

CiteScore

5.30

自引率

0.00%

发文量

审稿时长

103 days