Tratamiento farmacológico en la fibromialgia

Some drugs have proven efficacy in controlling the clinical symptoms of fibromyalgia. The drugs with the greatest demonstrated efficacy are tricyclic antidepressants (e.g. amitriptyline or cyclobenzaprine), selective serotonin reuptake inhibitors (e.g. fluoxetine), serotonin and norepinephrine reuptake inhibitors (e.g. duloxetine and milnazipram), some analgesics such as acetaminophen, alone or in combination with tramadol, and some anticonvulsant drugs such as pregabalin.

Other drugs such as non-steroidal antiinflammatory agents, major opioids, hormonal treatments and herbal medicines have shown no efficacy in clinical trials and consequently are not recommended in the treatment of fibromyalgia.

Some antidepressants, such as venlafaxine, moclobemide, pirlindole, mirtazapine and bupropion, have shown efficacy in some studies but more clinical trials are required before they can be recommended in patients with fibromyalgia.

Dopamine agonist receptors may be a good option in the future for the treatment of fibromyalgia if preliminary clinical studies with these drugs are confirmed.