N.I. Manjarres-Posada, L.A. Choconta-Piraquive, F. De la Hoz-Restrepo
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引用次数: 0
摘要
对2631名哥伦比亚2岁儿童进行了回顾性队列研究，以评估肺炎球菌疫苗的有效性。使用Cox比例风险模型评估疫苗接种与疾病之间的关联。接种疫苗的儿童所有结局的住院风险均显著降低(HR 0.59 CI 95% 0,42 - 0.85)，肺炎的住院风险降低略高(HR 0.53 CI 95% 0,32 - 0.89)。我们的研究结果显示，在接种疫苗的儿童中，可能与肺炎球菌相关的临床综合征的风险显著降低，证实了在中等收入发展中国家使用结合疫苗的益处。
Evaluating the effectiveness of conjugated pneumococcal vaccines in Colombia
A retrospective cohort study was conducted in 2631 Colombian children <2 yrs to evaluate pneumococcal vaccine effectiveness. Association between vaccination and disease was evaluated using Cox proportional hazards models. Vaccinated children had a significant reduction in hospitalization risk for all outcomes (HR 0,59 CI 95% 0,42 - 0,85) and for pneumonia the reduction was slightly higher (HR 0,53 CI 95% 0,32 - 0,89). Our results show an important risk reduction in clinical syndromes potentially associated to pneumococcus in vaccinated children confirming the benefits of using conjugate vaccines in a medium income developing country.
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