Shahriar Ahmed , Ahmed Rakib , Mir Muhammad Nasir Uddin , Mohammad Safiqul Islam , S.M. Amanat Ullah , Talha Bin Emran
{"title":"reelin基因(RELN)多态性与孟加拉国人群自闭症谱系障碍的关联","authors":"Shahriar Ahmed , Ahmed Rakib , Mir Muhammad Nasir Uddin , Mohammad Safiqul Islam , S.M. Amanat Ullah , Talha Bin Emran","doi":"10.1016/j.mgene.2021.100901","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>This study was conducted to detect the two single-nucleotide polymorphisms (SNPs) (g.333509A > C and g.504742G > A) of the reelin (<em>RELN</em>) gene and to detect their association with autism spectrum disorder (ASD) in the Bangladeshi population.</p></div><div><h3>Methods and materials</h3><p>Polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing were performed to identify the SNPs, and their association with ASD was evaluated in a total of 216 Bangladeshi people, which included 108 autistic patients and 108 healthy participants.</p></div><div><h3>Results</h3><p>The alleles and genotype frequencies of g.333509A > C and g.504742G > A showed no significant relationship with ASD (χ<sup>2</sup> = 0.603; <em>p</em> = 0.479 and χ<sup>2</sup> = 0.274; <em>p</em> = 0.601, respectively).</p></div><div><h3>Conclusions</h3><p>Our findings indicate that these two variants of the <em>RELN</em> gene do not seem to be related with ASD in the Bangladeshi population. Therefore, further studies are suggested for identifying the SNPs of the <em>RELN</em> gene responsible for ASD in the Bangladeshi population.</p></div>","PeriodicalId":38190,"journal":{"name":"Meta Gene","volume":"29 ","pages":"Article 100901"},"PeriodicalIF":0.8000,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.mgene.2021.100901","citationCount":"1","resultStr":"{\"title\":\"Association of reelin gene (RELN) polymorphism with autism spectrum disorder in the Bangladeshi population\",\"authors\":\"Shahriar Ahmed , Ahmed Rakib , Mir Muhammad Nasir Uddin , Mohammad Safiqul Islam , S.M. Amanat Ullah , Talha Bin Emran\",\"doi\":\"10.1016/j.mgene.2021.100901\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><p>This study was conducted to detect the two single-nucleotide polymorphisms (SNPs) (g.333509A > C and g.504742G > A) of the reelin (<em>RELN</em>) gene and to detect their association with autism spectrum disorder (ASD) in the Bangladeshi population.</p></div><div><h3>Methods and materials</h3><p>Polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing were performed to identify the SNPs, and their association with ASD was evaluated in a total of 216 Bangladeshi people, which included 108 autistic patients and 108 healthy participants.</p></div><div><h3>Results</h3><p>The alleles and genotype frequencies of g.333509A > C and g.504742G > A showed no significant relationship with ASD (χ<sup>2</sup> = 0.603; <em>p</em> = 0.479 and χ<sup>2</sup> = 0.274; <em>p</em> = 0.601, respectively).</p></div><div><h3>Conclusions</h3><p>Our findings indicate that these two variants of the <em>RELN</em> gene do not seem to be related with ASD in the Bangladeshi population. Therefore, further studies are suggested for identifying the SNPs of the <em>RELN</em> gene responsible for ASD in the Bangladeshi population.</p></div>\",\"PeriodicalId\":38190,\"journal\":{\"name\":\"Meta Gene\",\"volume\":\"29 \",\"pages\":\"Article 100901\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2021-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.mgene.2021.100901\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Meta Gene\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2214540021000529\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"GENETICS & HEREDITY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Meta Gene","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2214540021000529","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
Association of reelin gene (RELN) polymorphism with autism spectrum disorder in the Bangladeshi population
Purpose
This study was conducted to detect the two single-nucleotide polymorphisms (SNPs) (g.333509A > C and g.504742G > A) of the reelin (RELN) gene and to detect their association with autism spectrum disorder (ASD) in the Bangladeshi population.
Methods and materials
Polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing were performed to identify the SNPs, and their association with ASD was evaluated in a total of 216 Bangladeshi people, which included 108 autistic patients and 108 healthy participants.
Results
The alleles and genotype frequencies of g.333509A > C and g.504742G > A showed no significant relationship with ASD (χ2 = 0.603; p = 0.479 and χ2 = 0.274; p = 0.601, respectively).
Conclusions
Our findings indicate that these two variants of the RELN gene do not seem to be related with ASD in the Bangladeshi population. Therefore, further studies are suggested for identifying the SNPs of the RELN gene responsible for ASD in the Bangladeshi population.
Meta GeneBiochemistry, Genetics and Molecular Biology-Genetics
CiteScore
1.10
自引率
0.00%
发文量
20
期刊介绍:
Meta Gene publishes meta-analysis, polymorphism and population study papers that are relevant to both human and non-human species. Examples include but are not limited to: (Relevant to human specimens): 1Meta-Analysis Papers - statistical reviews of the published literature of human genetic variation (typically linked to medical conditionals and/or congenital diseases) 2Genome Wide Association Studies (GWAS) - examination of large patient cohorts to identify common genetic factors that influence health and disease 3Human Genetics Papers - original studies describing new data on genetic variation in smaller patient populations 4Genetic Case Reports - short communications describing novel and in formative genetic mutations or chromosomal aberrations (e.g., probands) in very small demographic groups (e.g., family or unique ethnic group). (Relevant to non-human specimens): 1Small Genome Papers - Analysis of genetic variation in organelle genomes (e.g., mitochondrial DNA) 2Microbiota Papers - Analysis of microbiological variation through analysis of DNA sequencing in different biological environments 3Ecological Diversity Papers - Geographical distribution of genetic diversity of zoological or botanical species.